摘要
目的探讨静脉泵入吗啡在癌痛滴定治疗中的临床应用效果。方法 60例恶性肿瘤患者,依据镇痛方式的不同分为对照组(口服吗啡)和观察组(静脉泵入吗啡),各30例。观察并比较两组患者滴定前后疼痛程度评分、生活质量评分、疼痛缓解时间、疼痛程度、用药后3 d不良反应发生情况。结果滴定前,两组患者疼痛程度评分和生活质量评分比较,差异均无统计学意义(P>0.05)。滴定后,两组患者疼痛程度评分均低于滴定前,生活质量评分均高于滴定前,差异有统计学意义(P<0.05);观察组患者疼痛程度评分低于对照组,生活质量评分高于对照组,差异有统计学意义(P<0.05)。观察组患者疼痛缓解时间为(76.2±9.6)min,明显短于对照组的(261.5±10.2)min,疼痛程度分级优于对照组,差异均有统计学意义(P<0.05)。观察组患者用药后3 d不良反应发生率为33.3%,低于对照组的63.3%,差异有统计学意义(P<0.05)。结论静脉泵入吗啡在癌痛患者治疗中的应用,可以尽快缓解患者的疼痛,改善其生活质量,降低不良反应发生率,值得临床推广应用。
Objective To discuss the clinical effect of intravenous injection of morphine in the treatment of cancer pain titration. Methods A total of 60 patients with malignant tumor were divided by different analgesic modes into control group (oral administration of morphine) and observation group (intravenous injection of morphine), 30 cases in each group. Observation and comparison were made on pain score and quality of life score before and after titration, pain relief time, pain degree and occurrence of adverse reactions at 3 d after medication between the two groups. Results Before titration, both groups had no statistically significant differences in pain degree score and quality of life score (P>0.05). After titration, both groups had lower pain degree score and higher quality of life score than those before titration. The differences were statistically significant (P<0.05). The observation group had lower pain degree score and higher quality of life score than the control group. The differences were statistically significant (P<0.05). The observation group had obviously shorter pain relief time as (76.2±9.6) min than (261.5±10.2) min in the control group, and better pain degree grading than the control group. The differences were statistically significant (P<0.05). The observation group had lower incidence of adverse reactions at 3 d after medication as 33.3% than 63.3% in the control group, and the difference was statistically significant (P<0.05). Conclusion Intravenous infusion of morphine in the treatment of cancer pain can relieve the pain of patients as soon as possible, improve their quality of life and reduce the incidence of adverse reactions. It is worthy of clinical promotion and application.
作者
邓婉芳
罗承东
邢世江
曾维斌
黄丽云
李新
许家健
DENG Wan-fang;LUO Cheng-dong;XING Shi-jiang(Zhongshan Xiaolan People's Hospital, Zhongshan 528415, China)
出处
《中国实用医药》
2018年第36期13-15,共3页
China Practical Medicine
关键词
癌痛
吗啡
口服
静脉泵入
Cancer pain
Morphine
Oral administration
Intravenous infusion
