摘要
目的 应用多普勒组织成像 (DTI)技术定量定位分析生理和病理 (心肌缺血 )状态下左心室局部收缩和舒张功能。方法 研究对象为 15 5例确诊冠心病的患者 (冠心病组 )和 41例年龄匹配的正常人 (对照组 )。采用心尖四腔、心尖二腔和心尖长轴切面 ,每个室壁又选择两个取样点分别位于该室壁的基底部和中部 ,分别显示左心室 6个室壁 12个节段运动的情况。DTI测量参数包括收缩功能指标 :心肌收缩峰值速度 (VS)和心肌收缩峰值时间 (TS) ;舒张功能指标 :心肌舒张早期峰值速度 (VE)、心肌舒张早期峰值时间 (TE)和VE 与舒张晚期峰值速度 (VA)的比值 (VE/VA)。结果 与对照组相比 ,冠心病组DTI可敏感地定量显示出收缩和舒张峰值速度显著下降以及峰值时间的显著延长 ;前壁心肌梗死时可见病变区多个节段多项DTI收缩和舒张功能参数异常 ,DTI收缩与舒张速度指标之间、收缩速度与左室射血分数之间以及舒张功能参数VE/VA 均值与二尖瓣血流频谱E/A比值之间存在高度相关性。
Objective To quantitatively assess regional left ventricular(LV) systolic and diastolic function in physiological and pathological(myocardial ischemia) condition by Doppler tissue imaging(DTI) technique.Methods One hundred and fifty five patients with coronary artery disease (CAD) and 41 age matched healthy subjects as control group were included. Apical 4 chambers, 2 chambers and long axis views were performed with pulsed sample volume at the basal and middle levels,which could show 12 segments of 6 LV walls. Peak systolic velocity (V S), time to peak systolic velocity(T S), peak early diastolic velocity(V E), time to peak diastolic velocity(T E), and peak late diastolic velocity(V A) were measured in each segment and V E/V A ratio was calculated.Results Compared with control group, decreased V S, V E, and diastolic velocities and delayed time to peak velocity were sensitively detected by DTI in CAD group. In the case of anterior wall infarction DTI showed abnormal systolic and diastolic indexes in the involved segments.Also, there were close relations between DTI systolic and diastolic indexes, between DTI systolic indexes and LVEF(M mode), and between V E/V A(mean) and transmitral indexes E/A ratio.Conclusion As a new method of quantitatively assessing regional LV function, DTI has a potential value in the non invasive diagnosis of CAD.
出处
《中华超声影像学杂志》
CSCD
2000年第10期581-584,共4页
Chinese Journal of Ultrasonography
基金
香港大学医学院 1 999/ 2 0 0 0年度IvyWu基金资助 !(DocM46/ 394)
关键词
多普勒组织成像
左心室功能
冠心病
诊断
Doppler tissue imaging
Coronary disease
Ventricular function,left
