摘要
目的:探讨甲状腺功能亢进性心脏病(甲亢性心脏病,HHD)患者早期血清B型脑钠肽(BNP)水平和左心功能的关系。方法:采用酶联免疫吸附法(ELISA)和彩色多普勒超声心动图技术检测86例甲亢性心脏病(HHD组)和57例健康对照者(对照组)血清BNP的水平和左室二尖瓣舒张早期(E峰)及舒张晚期(A峰)最大血流速度,计算E/A比值。结果:HHD组血清BNP水平显著高于正常对照组(t=4.27,P<0.01),二尖瓣血流频谱E/A比值显著低于正常对照组(t=2.18,P<0.05),BNP与E/A比值之间存在显著负相关(r=-0.37,P<0.01)。结论:血清BNP水平结合二尖瓣血流频谱E/A比值可早期诊断和评估HHD的心功能。
Objective： To investigate the relationship between the serum brain natriuretic peptide （ BNP） and left ventricular function in the patients with hyperthyriod heart disease. Method： Eighty six pa- tients with hyperthyriod heart disease and fifty seven normal controls were studied. The serum levels of BNP were measured with competitive enzyme immunoassay kit. the peak value of mitral annular early diastolic velocity （E） and late diastolic velocity （A ） were measured with doppler echocardiography. Result： The serum levels of BNP were significantly higher in the patients with hyperthyriod heart disease than those of normal subjects（ t =4.27 ,P 〈0.01）. valva mitralis prised- wave rate of E/A were lower than subjects（ t =2.18 ,P 〈 0.05 ）. BNP correlated negatively with E/A （ r -- - 0.37, P 〈 0.01 ）. Conclusion： HHD was earlier diagnosed and its left ventricular function was assesssd by BNP and E/A.
出处
《河北医学》
CAS
2007年第11期1280-1282,共3页
Hebei Medicine
关键词
B型脑钠肽
甲亢性心脏病
心功能
Brain natriuretic peptide
Hyperthyriod heart disease
Ventricular function
