摘要
【目的】探讨氯硝西泮治疗慢性癫痫患者的有效性和安全性。【方法】对119例癫痫患者进行回顾性分析。治疗组54例，服用常规抗癫痫药物联合氯硝西泮。对照组65例服用常规抗癫痫药物，包括卡马西平、丙戊酸、奥卡西平、拉莫i秦、妥泰、左乙拉西坦、苯妥英钠等。有效性评价指标为发作控制率，安全性评价指标为不良事件的发生率。【结果】（1）疗效分析：治疗组：常规抗癫痫药物联合氯硝西泮开始有效，2-4个月后疗效下降，发作控制率50％以上；对照组：48例（52．30％）患者认为服用一种抗癫痫或联合用药后有效，且疗效维持。服药6个月后两组比较结果显示，氯硝西泮组疗效低于对照组（P=0．02）。（2）安全性分析：①治疗不良反应：治疗组：该药服用6个月或以上，不良反应发生率为98％，最常见不良反应依次为嗜睡占51．85％，健忘占48．15％，注意力不集中占37．04％，头晕或眩晕占37．04％，头痛占37．04％等，明显高于对照组（P〈0．05）。②撤药不良反应：治疗组撤药后发作加重、癫痫持续状态、焦虑、失眠、紧张等。90％的患者曾存在不规范服药，包括间断服药，或突然撤停，或自行增减剂量。【结论】氯硝西泮对癫痫疗效维持时间短，副作用发生率高，选药时应严格掌握适应症。
[ Objective ] To explore the efficacy and safety of clonazepam in treating epilepsy patients. [ Methods ] Data of 54 epilepsy patients treated with clonazepam alone or combined with other drug（s） six months or longer were analyzed retrospectively. Epilepsy control rate was used to evaluate the efficacy and incidence rate of side-effects was used to evaluate the safety. [Results] （1）Efficacy analysis： 81.48% showed effectively at the beginning of treatment and the control rate was higher than 50%, but the efficacy decreased 2-4 months later. （2）Safety analysis： Side-effects of treatment： Treatment groups：incidence rate of side-effects was 98% after six months or longer treatment of clonazepam. The side-effects included somnolence 51.85%, forgettery 48.15%, dizzy 37.04% and headache 37.04%. Withdrawal syndrome： frequent attacks, status epilepticus, anxiety, insomnia, intensity, et al. 90% patients didn＇t take drug according to doctor＇s orders. [Conclusions] Clonazepam with short-term efficacy but high incidence rate of side-effects in patients with epilepsy. Therefore it should be used very carefully.
出处
《武警后勤学院学报（医学版）》
CAS
2013年第10期886-889,共4页
Journal of Logistics University of PAP（Medical Sciences）
