摘要
目的观察颈痛汤配合针刺治疗对椎动脉型颈椎病(CSA)患者的临床疗效和血清白介素(IL)-1β、一氧化氮(NO)、转化生长因子(TGF)-β1的影响。方法 136例CSA患者随机分为治疗组和对照组各68例,治疗组采用颈痛汤配合针刺治疗,对照组采用口服盐酸氟桂利嗪胶囊和颈椎牵引治疗,68例健康对照组空白治疗。治疗后观察临床疗效和血清IL-1β、NO、TGF-β1的变化。结果治疗组与对照组的总有效率分别为91.18%和79.41%,差异有统计学意义(P<0.05)。治疗组血清IL-1β、NO、TGF-β1浓度治疗前后组内比较,差异有统计学意义(P<0.05);治疗后,治疗组与对照组比较,差异有统计学意义(P<0.05),与健康组比较差异无统计学意义(P>0.05)。结论颈痛汤配合针刺治疗临床疗效显著,对CSA患者血清IL-1β、NO、TGF-β1的影响明显。
Objective： To observe the effect of Jingtong Decoction and acupuncture in the treatment of vertebray artery-type cervical spondylopathy （CSA） and the influence of IL-1β、NO and TGF-β1 in serum. Methods： 136 cases with CSA were randomly divided into the treatment group with 68 cases and the control group with 68 pa- tients. The patients in the treatment group were treated with Jingtong Decoction and acupuncture. The subjects in control group were treated with flunarizine capsule and cervical traction. And blank treatment in 68 cases were the healthy control group.Mter treatment,some indicators were observed such as the clinical curative effect and the changes of IL-1β、NO and TGF-β1, in serum. Results： The total effective rate was 91.18% in the treatmen group and 79.41% in the control group. There was a statistical difference between 2 groups （P〈0.05）.The levels of IL-113 ,NO and TGF-[3~ in the treatment group were improved obviously after treatment （P〈 0.05）. Meanwhile, there were statistical significant between the treatment group and the control group （P 〈 0.05）,not between the treatment group and the healthy control group（P〉 0.05）. Conclusion： The therapeutic effects on CSA treated with both Jingtong Decoction and acupuncture are preferable. It has a obvious influence to IL-1β、NO and TGF-β1, in CSA patients.
出处
《中国中医急症》
2013年第12期2042-2044,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省深圳市宝安区2012年科技计划(医疗卫生类)社会公益项目(2012183)
