摘要
目的评价祛铁治疗对再生障碍性贫血患者造血恢复的作用。方法 1例重型再生障碍性贫血患者经免疫抑制治疗11个月,外周血细胞水平无明显改善,并出现输血相关铁过载。加用祛铁胺规律祛铁治疗。结果祛铁治疗5个月后患者脱离血小板输注,7个月脱离红细胞输注,9个月停止祛铁治疗,13个月外周血细胞水平恢复正常,无不良反应发生。结论对输血依赖的骨髓衰竭患者,应密切监测血清铁蛋白水平变化,出现铁过载后及时进行祛铁治疗,有助于患者造血恢复。
Objective To evaluate the effect of iron chelation therapy on hematologic response in a patient with severe aplastic anemia. Methods A patient diagnosed as severe aplastic anemia was treated with immunosuppressive therapy. Eleven months later, no improvement on peripheral blood cell count was available and transfusion-related iron overload was confirmed. Therefore, regular iron chelation therapy with deferoxarnine was administrated. Results The patient became platelet transfusion-independent in 5 months from the beginning of iron chelation therapy, red blood cell transfusion-independent in 7 months, and the iron chelation therapy lasted 9 months. A complete remis- sion was achieved in 13 months from the beginning of iron chelation therapy, and no adverse effect happened. Conclusion Monitoring serum ferritin is necessary to transfusion-denpendent patients with bone marrow failure, and timely iron chelation therapy is helpful to achieve hematologic response for iron overload patients.
出处
《中国药物警戒》
2013年第12期764-766,共3页
Chinese Journal of Pharmacovigilance
基金
国家自然科学基金资助项目(编号81000200)
北京市卫生系统高层次卫生技术人才培养项目(编号2011-3-092)
关键词
祛铁治疗
再生障碍性贫血
造血恢复
iron chelation therapy
aplastic anemia
hematologic response
