摘要
应用抗卤虫(Artemia salina)生物活性筛选模型,分析南海毛蚶(Scapharca subcrenata)乙醇浸膏和正丁醇相的生物活性成分。从毛蚶(S.subcrenata)正丁醇萃取相中共分得4个化合物,包括3个甾体类化合物5-烯-胆甾醇(1),胆甾醇(2),3-酮-20-烯孕甾烷(3)和1个吲哚类化合物3-carboxy-indole(4),化合物(1)^(3)在50μg/mL时对卤虫的致死率分别为65.0%,60.0%和58.3%。
The bioactivities of ethanolic extract and n-butanol fractions of Scapharca subcrenata from the South China Sea were evaluated by the model of lethality to brine shrimp Artemia salina.The ethanolic extract and n-butanol fractions showed lethality.The compounds in the n-butanol were separated,and four compounds were identified as cholest-5-en-3-ol （1）,Cholesterol （2）,5a-pregn-20-en-3-one （3） and 3-carboxy-indole （4）.The compounds 1～3 belong to sterols and their lethal rate was 65.0%,60.0% and 58.3% in 50μg/mL,respectively,suggesting that these steroids should be the bioactive substances of S.Subcrenata lischke.
出处
《广西科学》
CAS
2013年第4期272-275,共4页
Guangxi Sciences
基金
广西科学研究与技术开发计划项目(桂科攻11107011-8)
广西科学研究与技术开发计划项目(桂科攻11107011-6)资助
广西科学院基本科研业务费项目(13YJ22HYS15)
关键词
毛蚶
甾体
生物活性
Scapharca subcrenata lischke
steroids
bioactivity
