摘要
目的研制黄芩苷缓释微囊并进行稳定性考察。方法运用复凝聚法以明胶和阿拉伯胶为囊材,黄芩苷为囊心物,吐温-80为润湿剂制备微囊。以包封率作为质量判定指标,采用单因素考察和正交试验优化处方工艺。结果得出最优处方是明胶和阿拉伯胶浓度皆为1.33%g/mL,反应温度50℃,pH值3.90,材药比为5:1。按该处方制得的微囊囊型圆整光滑,载药量较高,并具有一定的缓释效果。结论复凝聚法可成功制备出包封率较高的黄芩苷微囊,且产品稳定性良好。该法可操作性强,重复性好,有一定的实用价值。
Objective： To developing sustained release microcapsules of baicalin and investigate its stability. Methods： The baicalin microcapsules were prepared by using gelatin and arabic gum as wall materials, baicalin as core and Tween-80 as wetting agent. Encapsulation efficiency as the quality indicator, the formulation and technology was optimized by single phoneme and orthogonal experiment. Results： The optimum parameters were that the concentrations of both gelatin and arabic gum were 1.33% g/mL, the temperature was 50 ℃, pH was 3.90, and the ratio of wall materials to core was 5：1. The prepared baicalin microcapsules were spherical with smooth surface, high encapsulation efficiency and time-release effect. Conclusion： The baicalin microcapsule could be prepared by complex coacervation method with good stability successfully. This method was easily operated with good repeatability and strong maneuverability.
出处
《井冈山大学学报（自然科学版）》
2013年第6期88-92,共5页
Journal of Jinggangshan University (Natural Science)
关键词
黄芩苷
复凝聚法
微囊
正交试验
稳定性
baicalin
complex coacervation
microcapsule
orthogonal experiment stability
