摘要
目的:制备蛇床子素缓释微囊并考察其体外释放规律。方法:以明胶、阿拉伯胶为囊材,采用复凝聚法制备微囊,采用紫外分光光度法测含量,均匀设计优化制备工艺。分别以150 mL人工胃液与磷酸盐缓冲液(pH 6.8)为溶出介质,温度(37±0.5)℃,转速100 r·min-1,测定其体外释放度。结果:最佳制备工艺为囊心囊材质量比1∶1.5,温度60℃,戊二醛用量0.8∶120(戊二醛用量/系统体积),制备的微囊圆整光滑,粒径均匀,平均粒径(51.6±4)μm,包封率85.0%,载药量47.2%,体外缓释时间为6 h,其释药特征符合一级动力学过程。结论:蛇床子素微囊制备工艺简单,成囊性和重复性好,微囊具有明显的缓释效果。
Objective：To prepare osthol microcapsules and study its release rate in vitro.Method： Osthol microcapsules were prepared by complex coacervation using gelatin-acacia and uniform design.Osthol content was determined by UV.150 mL artificial gastric and PBS（pH 6.8） were used as releasing media,the temperature was（37±0.5） ℃ and the rate of rotation was 100 r·min-1.Result： The optimized conditions were： the ratio of osthol and coating material of 1∶1.5,temperature of 60 ℃ and a hardening agent of 0.8 per 120 of coacervation system.The microcapsules were round under sphere.The average microcapsules diameters were（51.6±4）μm.And the content of osthol was 47.2% with coating ratio of 85.0%.The microcapsules could be released for 6 h in vitro and its releasing curve fit first-order dynamic equations.Conclusion： The preparation method is simple and osthol microcapsules have obvious sustained-release effect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第13期8-11,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河北省中医药管理局项目(2009065)
张家口市科技计划子项目(1012011D-2)
关键词
蛇床子素
微囊
均匀设计
复凝聚
体外释放度
osthol
microcapsule
uniform design
complex coacervation
release rate in vitro
