摘要
目的 观察比较 6种眼科外用药物 ,为临床筛选较强的抑制胶原酶的眼液。方法用鼠胶原、胶原酶及考马斯亮蓝比色法来检测药物抑制胶原酶的能力。结果 6种药物有不同程度抑制胶原酶作用 ,其中卡托普利极强、乙酰半胱氨酸和依地酸钠较强 ,而枸橼酸钠、硫代硫酸钠和四环素较差。结论 0 .5 g· L- 1卡托普利眼液抑制胶原酶能力极强、副作用小、刺激性极微。
Objective To investigate, compare and filtrate the collagenase inhibitor effects among six kinds of eye drops for clinical use.Methods The collagenase inhibitor’s effects were detected by rat's collagen and collagenase with comassie brilliant blue colorimetric method.Results The inhibitting collagenase effects among six kinds of eye drops were different: the effect of cartopril was the strongest;the acetylcysteine and sodium edetate were more strong and the sodium citrate, sodium hyposulfite and tetracycline were less strong.Conclusion 0.5g·L -1 cartopril eye drops has stronger efficacy to inhibit collagenase, with less side effect or stimulation,more convenient resource and preparation than other eye drops.
出处
《眼科新进展》
CAS
2000年第6期426-427,共2页
Recent Advances in Ophthalmology
关键词
胶原酶抑制剂
滴眼剂
考马斯亮蓝比色法
collagenase
collagenase inhibitor
comassie brilliant blue colorimetric method
cartopril
