摘要
目的探讨急性脑梗死患者血抵抗素、脂联素水平的改变及其与颈动脉粥样硬化和脑卒中危险因素的关系。方法检测113例急性脑梗死患者的血清抵抗素、脂联素(酶联免疫吸附测定法)及血糖、血脂、超敏C反应蛋白(hs-CRP)水平和血压,用彩色多普勒超声仪检测颈动脉;并与正常对照组进行比较。对血抵抗素水平与其他观察指标的相关性及影响因素进行分析。结果急性脑梗死组的血清抵抗素水平显著高于正常对照组(P<0.001)、脂联素水平显著低于正常对照组(P<0.01)。多因素非条件Logistic回归分析显示,抵抗素、年龄、血压、低密度脂蛋白(LDL)、hs-CRP为颈动脉粥样硬化的危险因素。血抵抗素水平与血糖、LDL、hs-CRP、颈动脉内-中膜厚度(IMT)、粥样硬化斑块评分呈正相关(r=0.16～0.31,均P<0.05),与脂联素、高密度脂蛋白(HDL)呈负相关(r=-0.23～-0.26,均P<0.05)。结论急性脑梗死患者的血清抵抗素水平显著升高、脂联素明显降低。抵抗素是颈动脉粥样硬化的危险因素,与血糖、LDL、hs-CRP和颈动脉粥样硬化程度正相关;而脂联素与其呈负相关。
Objective To explore the change of level of serum resistin, adiponectin and its correlation with carotid atheroseclerosis and cerebral stroke risk factors in acute cerebral infarction patients. Methods The level of serum resistin, adiponectin （ELISA） and glucose, lipids, high-sensitive C-reactive protein （hs-CRP） , blood pressure were detected in all patients. Using the colour Doppler uhrasonography technique ,the carotid intima medial thickness, position of plaques were measured in 113 cases with acute cerebral infarction, and compared with those in 107 cases in the controlled group. The correlation and its influence factors between serum resistin levels arid others were analyzed. Results The level of serum resistin in acute cerebral infarction group were significantly higher than the control group （P 〈 0. 001 ） , while the level of serum adiponectin were significantly lower than the control group（ P 〈 0. 01 ）. Blood pressure, age, low-density lipoprotein （LDL） , resistin, adiponctin, hs-CRP were the major risk factors of earotid atherosclerosis which were shown recess analysis by Logistic. The level of serum resistin was positively correlated with the carotid intima medial thickness, plaque scores, high-density lipoprotein （HDL） and hs-CRP in serum was negatively correlates. Conclusions The level of serum resistin in acute cerebral infarction patients is significantly increased, while the levels of serum adiponectin were significantly reduced. The resistin is the risk factor of carotid atherosclerosis.
出处
《临床神经病学杂志》
CAS
北大核心
2013年第6期404-407,共4页
Journal of Clinical Neurology
基金
江苏省自然科学基金资助项目(BK2008249)
江苏省"六大人才高峰"资助D类项目
镇江市社会发展科技支撑项目(SH2010021)
关键词
急性脑梗死
抵抗素
脂联素
颈动脉粥样硬化
acute cerebral infarction
adiponectin
resistin
earodit atheroseclerosis
