摘要
黑素瘤源于神经脊黑素细胞,是侵袭性最强的恶性肿瘤之一。小眼畸形相关转录因子(microphthalmiaassociated transcription factor,MITF)不仅是黑素细胞生长、分化及色素生成的主要调节蛋白,其对黑素细胞的恶性转化以及黑素瘤的发生、发展及转移也发挥着重要的作用。本文将针对MITF在黑素瘤中的调控功能及其相关分子通路作一综述,以期寻找黑素瘤分子治疗的作用靶点。
Melanoma arises from the melanocyte cell lineage, it is one of the most notoriously aggressive and treatment-resistant human cancers. Microphthalmia-associated transcription factor （MITF） acts as a master regulator of melanocyte＇s development, function and survival by modulating various differentiation and cell-cycle progression genes. It also plays an oncogenic role in melanoma. MITF targeting genes important in melanoma progression include promoting survival and blocking apoptosis, stimulating proliferation, and inhibiting cell cycle. This review summarized the molecular function of MITF and its related pathways, and hope it will shed light on strategies for improving therapeutic approaches for melanoma.
出处
《肿瘤》
CAS
CSCD
北大核心
2013年第12期1130-1134,共5页
Tumor
关键词
黑素瘤
小眼畸形相关转录因子
信号转导
细胞转化
Melanoma
Microphthalmia-associated transcription factor
Signal transduction
Celltransdifferentiation
