摘要
丝裂原活化蛋白激酶路径是一种细胞外信号蛋白激酶转导途径,参与了黑素瘤的生长侵袭和转移等过程,其中丝裂原活化蛋白激酶/细胞外信号调节激酶路径与黑素瘤的关系最为密切。目前认为,该信号转导路径中的RAS、ERK,尤其是BRAF激酶在黑素瘤的发生发展中可能有重要作用。以MAPK/ERK路径为重点,主要介绍了BRAF、RAS和ERK等激酶分子与黑素瘤的关系。
Mitogen-activated protein kinase pathway （MAPK） is an extracellular signal protein kinase transduction pathway, extensively involved in the growth, invasion and metastasis of malignant melanoma （MM）. In the MAPK superfamily, the MAPK/ERK pathway is considered the most significant. It is recognized now that R.AS, ERK, especially BRAF kinase in the MAPK/ERK pathway probably play important roles in the development of MM. Stressing the MAPK/ERK pathway, the article mainly reviews the current understanding of the roles of BRAF, R.AS and ERK kinases in MM.
出处
《国际皮肤性病学杂志》
2006年第3期191-193,共3页
International Journal of Dermatology and Venereology
