摘要
目的观察降逆汤联合低强度氦-氖激光治疗反流性食管炎(RE)的临床疗效。方法将2011年1月—2012年3月浙江中医药大学附属第一医院收治的RE患者90例按随机数字表法分为中药组、西药组和联合治疗组,每组各30例,分别采用降逆汤、西药及降逆汤联合低强度氦-氖激光治疗8周,观察3组患者的临床症状及胃镜检查结果。结果临床症状评分比较:3组患者治疗前临床症状评分间差异无统计学意义(F=12.318,P=0.753);治疗后,中药组和西药组临床症状评分高于联合用药组(P<0.05),中药组和西药组间差异无统计学意义(P>0.05)。临床症状疗效比较:中药组显效4例、有效6例、无效20例,西药组显效2例、有效2例、无效25例,联合治疗组显效15例、有效12例、无效3例,3组临床症状疗效间差异有统计学意义(H=29.968,P=0.000),其中中药组和西药组间差异无统计学意义(P>0.05)。胃镜疗效比较:中药组显效2例、有效4例、无效5例,西药组显效2例、有效7例、无效8例,联合治疗组显效6例、有效4例、无效2例,3组胃镜疗效间差异有统计学意义(H=12.847,P=0.002),其中中药组和西药组间差异无统计学意义(P>0.05)。结论低强度氦-氖激光局部照射能够使受损的食管黏膜组织得到修复,炎症程度得到改善,结合降逆汤加味辨证治疗,使整体和局部双向调节疗效较单纯中药、西药治疗更为显著,适用于中重度的糜烂性RE患者。
Objective To observe the therapeutic effect of Jiangni decoction combined with low intensity helium - neon laser in treating reflux esophagitis. Methods A total of 90 patients with reflux esophagitis treated in the First Affiliated Hospital of Zhejiang Chinese Medical University between January 2011 and March 2012 were recruited. They were divided randomly into Chinese herb group （ n = 30） , western medicine group （ n = 30 ）, and the combined therapy group receiving Jiangni decoction combined with laser （ n = 30）. The medication in each group lasted for 8 weeks. The changes of clinical symptoms were ob- served, and gastroseopy were also applied to cheek the therapeutic effect after treatment. Resldts There was no statistically sig- nificant difference in the scores of clinical symptoms among the three groups before treatment （ F = 12. 318, P = 0. 753 ） ; How- ever, the scores of clinical symptoms in Chinese herb group and western medicine group were significantly higher than that of combined therapy group after treatment （ P 〈 0.05 ） , and there was no such significant difference between the Chinese herb group and the western medicine group （ P 〉 O. 05 ）. In the Chinese herb group, the medication was remarkably effeetive in improving the elinieal symptoms in 4 patients, effective in 6 patients, and ineffective in 20 patients; In the western medicine group, the medication was remarkably effective in improving the clinical symptoms in 2 patients, effective in 2 patients, and ineffective in 25 patients; And in the combined therapy group, the therapy was remarkably effective in improving the clinical symptoms in 15 patients, effective in 12 patients, and ineffective in 3 patients. There was significant difference in the efficacy of the medication related to the improvement of clinical symptoms among the three groups （ H = 29. 968, P = 0. 000）, but no such significant difference was noted between the Chinese herb group and the western medicine group （ P 〉0.05 ）. Based on the resul
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第32期3868-3871,共4页
Chinese General Practice
基金
2010年度浙江省研究生创新科研项目(YK2010075)
2011年浙江省中医药科学研究基金计划项目(2011ZB048)
关键词
食管炎
激光
气体
降逆汤
综合疗法
Esophagitis
Lasers, gas
JIANGNI DECOCTION
Combined modality therapy
