摘要
目的:探讨失眠动物模型的制作,并对其进行评价。方法:中医理论指导建立的失眠模型的方法主要是多因素造模法和单因素造模法。西医理论指导建立的失眠模型的方法主要是有物理法造模法(强迫运动法、水平台环境法、人为物理因素刺激法),化学制剂刺激法等。结果:失眠是临床最为常见的睡眠障碍类型,在其机制及防治方法研究过程中,通常选择适合的动物模型以验证实验及临床假说,进而有效地认识疾病的预防及发生、发展规律。结论:笔者从指导复制模型的不同理论体系(中医、西医)出发,对失眠模型的起源,动物选择,常用动物失眠动物模型的制作方法、评价指标进行系统的回顾,并展望日后可能的发展方向,以期为失眠症及催眠药物研究提供更多帮助。
Objective：To study the preparation and evaluation of insomnia animal models. Methods：The methods of establishing insomnia model under the guidance of TCM theory mainly were muhifactor molding method and single factor molding method. The methods of es- tablishing insomnia model under the guidance of western medicine theory were physical modeling method（ forced locomotion technique, platform technique,human physical factors stimulation method） , chemical stimulation method, etc. Results ： Insomnia is the most com- mon type of sleep disorder in clinic, in the study of its mechanism and prevention methods, we usually select appropriate animal models to validate the experimental and clinical hypothesis, so as to understand the prevention, occurrence and development laws of the disease effectively. Conclusion： From the different guidance theory of modeling（ traditional Chinese medicine, western medicine）, the article sys- tematic reviews the origin of insomnia model, animal selection, commonly used methods of making insomnia animal model, evaluation in- dex of insomnia animal model, and focus on its direction of development, in order to provide more help for insomnia and hypnotic drug research.
出处
《中医学报》
CAS
2013年第12期1846-1848,共3页
Acta Chinese Medicine
基金
上海市教育委员会预算内科研项目(编号:2010JW33)
上海市卫生局中医药科研基金(编号:2012QL019A)
上海市卫生局青年科研项目(编号:2009Y085)
上海市科委项目(编号:10DZ1973800)
上海市卫生局项目(编号:20110423)
关键词
失眠
动物模型
睡眠剥夺
多因素造模法
单因素造模法
强迫运动法
水平台环境法
人为物理因素刺激法
化学刺激法
insomnia
animal model
sleep deprivation
muhifactor molding method
single factor molding method
forced locomotiontechnique
platform technique
human physical factors stimulation method
chemical stimulation method
