摘要
探讨大肠癌癌旁移行粘膜p21表达的意义。方法：应用流式细胞术和细胞免疫荧光染色技术，对35例结直肠癌和癌旁移行粘膜的p21表达进行定量研究。结果：结直肠癌和癌旁移行粘膜的p21表达阳性率分别为65．7％和60.0％，但癌组织的p21表达量明显高于癌旁移行粘膜；p21表达阳性的移行粘膜全部分布于p21表达阳性的癌组织中。结论：癌旁移行粘膜属癌前病变，外科手术时应切除足够长度的p21表达阳性的移行粘膜，以防止术后局部复发癌。
To Study ras P21 expression in tran sitional mucosa adjacent to colorectal cancer. Methods:The oncogne ras P21 expression in 35 cases of colorectal cancer and their transitional mucoas were analysed quantitativelywith flow cytometry and cyto- immunofluorescence staining technique. Results: The posititve rate of ras P21 expessionwere 65. 7% and 60. 0% in colorectal carcinomas and fransitional mucosa respectively. Ras P21 expression was higher incolorectal adenocarcinomas than that of the transitional mucosa. The transitional mucosa that ras P21 expression were posi-tive were distributed in carcinomas of ras P21 positive expression. Conclusion: Transitional mucosa adjacent to cancer werepremalignant lesions, they should be thoroughly reasetsd during the operation in order to prevent local recurrence of can-cer.
出处
《泸州医学院学报》
1999年第4期288-289,共2页
Journal of Luzhou Medical College
