摘要
目的探讨TNF-α基因多态性与阻塞性睡眠呼吸低通气暂停综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)合并高血压的关系。方法 2009-2012年于本院行多导睡眠检查,结果为重度OSAHS的300例男性患者,其中OSAHS伴高血压者145例,并随机抽取100例健康男性对照,采用基因测序的方法,检测TNF-α启动区基因-308G>A和-863C>A的基因多态性。采用R×C列联表χ2检验统计OSAHS伴高血压组、单纯OSAHS组以及健康对照组之间TNF-α基因多态性的关系。结果 OSAHS合并高血压组TNF-α-308GA型基因频率分布明显降低,为4.1%,而单纯OSAHS组和健康对照组GA型基因所占比例增高,分别为11.6%和12.0%。TNF-α-863基因类型以CC型为主,各组之间的基因频率分布差异无统计学意义。结论 TNF-α-308GA型基因可能通过减少TNF-α表达而对OSAHS合并高血压具有保护作用,TNF-α-308GA型与OSAHS伴高血压存在一定关联。
Objective To study the relation between TNF-α polymorphism and obstructive sleep apnea hypopnea syndrome （OSAHS） accompanying hypertension. Methods Three hundred severe OSAHS male patients who underwent sleep examination in our hospital from 2009 to 2012 were included in this study. Of these patients, 145 with hypertension served as a hypertension group and 100 randomly selected healthy subjects served as a control group. Their promoter gene （-308G ＞ A and -863C ＞ A） polymorphism was detected by gene sequencing. Relation between TNF-α polymorphism and OSAHS was analyzed by χ2 test in OSAHS patients with hypertension, OSAHS patients and controls according to the R×C scale. Results The frequency of TNF-α-308GA was significantly lower in OSAHS patients with hypertension than in those without hypertension and healthy controls （4.1% vs 11.6% and 12.0%）. No significant difference was found in the TNF-α-308 mainly manifested as the CC genotype among the 3 groups. Conclusion TNF-α-308GA can protect the OSAHS patients with hypertension by reducing TNF-α expression and is related with OSAHS accompanying hypertension.
出处
《解放军医学院学报》
CAS
2013年第12期1265-1268,共4页
Academic Journal of Chinese PLA Medical School
基金
解放军总医院苗圃基金项目(09KMM18)
