摘要
目的:观察壳聚糖宫颈抗菌膜衬垫式介入治疗并发人乳头瘤病毒(human papillomavirus,HPV)感染的宫颈上皮内瘤CINⅢ型患者的临床疗效。方法:选取本院伴有HPV感染的宫颈上皮内瘤CINⅢ型患者152例,随机分为治疗组和对照组各76例。治疗组LEEP术后当天及第7、14、21天均行宫颈创面消毒,彻底擦拭干净消毒液后放置壳聚糖宫颈抗菌膜1枚于创面,并使抗菌膜紧贴创面,再向阴道内填塞带线棉球以防止抗菌膜脱落,12 h后取出。对照组术后未给予上述治疗。术后第7、14、21天均对两组患者复诊,观察阴道分泌物、阴道流血及创面愈合等情况。术后3个月复查宫颈行LCT及阴道镜检查。结果:术后第7、14、21天,治疗组阴道分泌物、阴道流血的综合评分和创面愈合情况及愈合时间均优于对照组,两组比较差异均有统计学意义(P<0.05)。治疗3个月后,对照组HPV感染转阴率为50.00%,治疗组为71.05%,两组比较差异有统计学意义(P<0.05)。电子阴道镜检查显示对照组慢性炎症转化率为55.27%,治疗组为34.21%,两组比较差异有统计学意义(P<0.05)。结论:壳聚糖宫颈抗菌膜衬垫式介入治疗伴有人乳头瘤病毒感染的宫颈上皮内瘤CINⅢ型患者有较好的治疗作用,值得推广应用。
Objective： To observe the clinical effect of patients of cervical intraepithelial neoplasia CINⅢ type with human papillomavirus （HPV）infection in chitosan cervical anti-bacterial membrane padded interventional therapy.Method： One hundred and fifty-two patients of cervical intraepithelial neoplasia CINⅢ type with HPV infection were randomly divided into the treatment group and the control group, each group had 76 cases. The same day and 7, 14, 21 days after operation of leep cutter technology, the treatment group was treated by cervical wound disinfection, put one chitosan cervical anti-bacteria membrane on the wound very close after thoroughly wiped clean disinfectant, filled the vagina with a cotton thread to prevent the anti-bacterial membrane falls off, then took it out after 12 h. The control group was not given above treatment after surgery. The indicators between the two groups were compared on 7, 14, 21 days after operation, such as vaginal discharge, vaginal bleeding and wound healing and so on. The LCT and colposcopy were used to check cervix after 3 months. Result：The indicators of vaginal discharge, the colligation score of vaginal bleeding and wound healing and the healing time of the treatment group were significantly better than the control group on 7, 14, 21 days after operation（P〈0.05）. The negative conversion rate of HPV infection of the control group was 50.00%, while the treatment group was 71.05% after 3 months, and the difference between the two groups were statistically significant（P〈0.05）. Electronic colposcope examination showed that the conversion rate of chronic inflammation of the control group was 34.21% while the treatment group was 55.27% after 3 months, and the difference between the two groups were statistically significant（P〈0.05）.Conclusion：The clinical effect of patients of cervical intraepithelial neoplasia CINⅢ type with human papillomavirus infection in chitosan cervical anti-bacterial membrane padded interventional therapy is excellent. It
出处
《中国医学创新》
CAS
2013年第33期13-15,共3页
Medical Innovation of China
关键词
宫颈上皮内瘤
HPV感染
壳聚糖宫颈抗菌膜
Cervical intraepithelial neoplasia
HPV infection
Chitosan cervical anti-bacterial membrane
