摘要
目的:检测病毒性心肌炎患儿外周血中CD3、CD4、CD8、CD4/CD8的值,探讨CD3、CD4、CD8、CD4/CD8在病毒性心肌炎中的作用,进一步为病毒性心肌炎的发病机理、发展以及治疗提供依据。方法:选择儿童病毒性心肌炎急性期病例30例,同时同群体选择健康儿童30例作为正常对照组。运用流式细胞仪检测病毒性心肌炎患儿及对照组的外周血中的CD3、CD4、CD8、CD4/CD8的值,进行分析比较。结果:CD3、CD4、CD8、CD4/CD8在病毒性心肌炎急性期的结果分别为CD3(%)55.77±7.0;CD4(%)11.0±5.1;CD8(%)41.9±3.3;CD4/CD8 0.26±0.1。正常对照组为CD3(%)71.6±8.4;CD4(%)38.5±4.8;CD8(%)31.9±7.2;CD4/CD8 1.25±0.25。表明病毒性心肌炎的急性期CD3、CD4、CD4/CD8的值降低,而CD8的值升高,差异有统计学意义(P<0.01)。结论:病毒性心肌炎的发病机制中有细胞免疫(T细胞)的失衡,而且细胞免疫在病毒性心肌炎的发生、发展中有重要作用。
Objective：To detect the values of CD3, CD4, CD8 and CD4/CD8 of peripheral blood in chil- dren with viral myocarditis, to explore the effect of CD3, CD4, CD8, CD4/CD8 on myocarditis, so as to pro- vide empirical evidence for the research into the pathogenesis of viral myocarditis, its development and treat- ment. Methods：30 cases of children with viral myocarditis at the acute stage were chosen as the experimental group, with 30 cases of healthy children as the controlled group. By means of flow cytometry assay, the values of CD3, CD4, CD8, and CD4/CD8 of peripheral blood in children from both groups were detected respectively; the analysis and comparison were made. Results： The values of CD3, CD4, CD8, CD4/CD8 at the acute stage of viral myocarditis were respectively CD3（ % ）55.77 -＋ 7.0 ; CD4（ % ） 11.0 ＋ 5.1 ; CD8（ % ）41.9 _＋ 3.3 ; CD4/CD8 0.26 ＋ 0.1 ; whereas in the controlled group, the results were as follows：CD3（ % ）71.6 ＋ 8.4;CD4（ % ）38.5 -＋ 4.8 ; CD8（ % ） 31.9 ＋ 7.2 ; CD4/CD8 1.25 -＋ 0.25 show that the values of CD3, CD4, CD4/CD8 at the acute stage of viral myocarditis decrease, while the value of CD8 increases. The differences were statistically significant （ P 〈 0.01 ）. Conclusion： The pathogenesis of viral myocarditis involves the imbalance of cellular immunity（T cells）. Cell - mediated immunity play an important role in the incidence and the development of viral myocarditis.
出处
《内蒙古医学杂志》
2013年第9期1042-1044,共3页
Inner Mongolia Medical Journal
关键词
病毒性心肌炎
儿童
细胞免疫
Keywords viral myocarditis
Children
Cellular Immunity CD3 CD4 CD8 CD4/CD8
