摘要
目的探讨联合检测心肌肌钙蛋白I(CTnI)和肌酸激酶同工酶(CK-MB),在诊断小儿病毒性心肌炎中的价值。方法CTnI测定采用酶联免疫夹心法,CK-MB采用全自动生化分析仪测定;并对CTnI、CK-MB两项指标联合检测的敏感度与特异度与两单项指标检测的敏感度与特异度进行比较。结果CTnI、CK-MB联合检测阳性率为81.1%,均显著高于CTnI(68.5%)CK-MB(70.1%),p<0.05;两项指标联合检测的敏感度均明显高于各单项指标单独检测的敏感度(P均<0.001),而联合检测的特异度与各单项指标单独检测的特异度无显著性差异(P>0.05)。结论CTnI、CK-MB联合检测与各单项指标单独检测相比较,特异度无显著性差异,敏感度显著增高,在临床上可提高小儿病毒性心肌炎的阳性诊断率。
Objective To evaluate the diagnostic values of the combination tests of serum cardiac troponin ICTnI) and creatine kinase-MBCK-MB) for determining the children patients with viral myocarditis.Methods Serum cTnl level was assayed by ELISA method with two monoclonal antibodies against cTnI,and serum CK-MB level was assayed by Automatic Biochemical Analysis Instrument.Then the sensitivity and specificity of the combination tests of the two markers group were compared with those of two single-marker groups.Results [WTBZ]The combination positive rate of cTnI and CK-MB was 81.1%,hlgher than the positive rate of cTnI-68.5%P<0.05),also higher than the positive rate of CK-MB-70.1%P<0.05).The sensitivity of the combination group was much higher than the each single-marker groupboth P<0.001),but there was no significant difference in specificity among themP>0.05).Conclusion The combination tests of serum cTnI and CK-MB group can raise the diagnostic positive rate of theChildren Patients with viral mvocarditis without decrease of the specificity statistically.
出处
《医学检验与临床》
2006年第1期15-16,共2页
Medical Laboratory Science and Clinics
