摘要
采用高压均质法制备阿瑞吡坦纳米混悬剂,以制备温度、均质压力和均质次数为考察对象,以粒径分布、多分散系数和?电位为评价指标,利用Box-Behnken效应面法优化阿瑞吡坦纳米混悬剂的制备工艺参数。所得优化的阿瑞吡坦纳米混悬剂的粒径为(352.4±21.4)nm,多分散系数为0.301±0.075,ζ电位为(-31.3±3.3)mV。透射电镜结果显示制品呈球形且粒径均一,45 min时溶出率为93.5%。
The aprepitant nanosuspensions were prepared by high pressure homogenization method. The effects of temperature, pressure and cycle times on the particle size, polydispersion index and ζ potential of the product were investigated by Box-Behnken design combined with response surface methodology. The particle size, polydispersion index and ζ potential of the optimal product were （352.4±21.4）nm, 0.301±0.075 and （-31.3±3.3）mV, respectively. The results of transmission electron microscope showed that the product was spherical and uniform. The dissolution at 45 min of the product was 93.5%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第12期1236-1239,1257,共5页
Chinese Journal of Pharmaceuticals
