摘要
目的探讨运用高压匀质技术制备齐墩果酸纳米悬浮液的可行性。方法以纳米粒粒径及多分散指数为指标,研究各影响因素如压力、循环次数、表面活性剂种类及用量对纳米悬浮液的影响。并研究纳米化齐墩果酸的溶解度及体外溶出行为。结果匀质压力是决定纳米粒粒径的最主要因素,增加循环次数可以使纳米粒的单分散性增加,表面活性剂对维持体系稳定性起着不可忽视的作用。纳米化齐墩果酸的溶解度及药物溶出速率得到明显提高。结论高压匀质技术可以成功用于制备齐墩果酸纳米悬浮液。
OBJECTIVE To study the preparation of oleanolic acid nanosuspension by means of high-pressure homogenization technique. METHODS Oleanolic acid nanosuspension was prepared with different pressure, homogenization cycles, and surfactants, Average particle size and the polydispensible index （PI） were measured to investigate the influences of these operation parameters on the nanosuspensions. The solubility and dissolution of drug nanoparticles were also investigated, RESULTS Homogenization pressure was the major factor that determined the average particle size, increased homogenization cycles led to a decreased PI, and suffactants helped to keep the system stable. Compared to crude drug powder, the solubility and dissolution of drug nanoparticles were evidently improved. CONCLUSION High-pressure homogenization technique can be used successfully to prepare oleanolic acid nanosuspensions.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第12期924-927,共4页
Chinese Pharmaceutical Journal
关键词
齐墩果酸
纳米悬浮液
高压匀质
oleanolic acid
nanosuspension
high-pressure homogenization
