摘要
目的探讨Axl与其配体生长停滞特异性蛋白6(Gas6)在乳腺癌中的表达及临床意义。方法采用免疫组化法检测96例乳腺癌及其配对癌旁正常组织中Axl和配体Gas6蛋白的表达情况,分析两者表达与乳腺癌临床病理特征的关系。结果 Axl在乳腺癌组织中阳性表达率为62.5%,高于其在癌旁正常组织中的17.7%(P<0.05);Gas6在乳腺癌中阳性表达率为54.2%,高于其在癌旁正常组织中的12.5%(P<0.05)。Axl蛋白表达与乳腺癌患者的年龄、肿瘤大小、组织学分级及c-erbB-2表达无关(P>0.05),与淋巴结转移、ER及PR表达有关(P<0.05);Gas6蛋白表达与年龄、肿瘤大小、PR表达及c-erbB-2表达无关(P>0.05),与淋巴结转移、组织学分级、ER表达有关(P<0.05)。乳腺癌组织中Axl与Gas6表达呈正相关(r=0.540,P<0.001)。结论 Axl与Gas6表达与乳腺癌的发生、发展有关。
Objective To investigate the expression and clinical significance of anexelekto（Axl） and its ligand growth arrest specific 6 （Gas6） in breast cancer.Methods Axl and its ligand Gas6 expression were examined in 96 cases of breast cancer and paired adjacent normal tissues by immunohistochemistry.The association between Axl and Gas6 protein expression and clinicopathological characteristics in breast cancer was further analyzed.Results Axl expression in breast cancer tissue（62.5%,60/96） was higher than that in adjacent normal breast tissue（17.7%,17/96） with significance（P 〈 0.05）.Axl ligand Gas6 expression in breast cancer tissue （54.2%,52/96） was higher than that in adjacent normal breast tissue （12.5 %,12/96） with significance （P 〈 0.05）.There was no relationship between Axl expression and age,tumor size,histological grade and c-erb-B2 expression,but it correlated with lymph node metastasis,ER and PR espression.Gas6 expression was correlated with lymph node metastasis,histological grade and ER expression,but not with age,tumor size,PR and c-erb-B2 expression.Axl expression was positively correlated with Gas6 expression in breast cancer（r =0.540,P 〈 0.001）.Conclusion Axl and Gas6 play an important role in the occurrence and invasion in breast cancer.
出处
《临床肿瘤学杂志》
CAS
2013年第11期978-981,共4页
Chinese Clinical Oncology
基金
辽宁省教育厅科学技术项目(L2010283)
