摘要
慢性前列腺炎是一种多病因引起的疾病,特征为会阴部不适、骨盆疼痛、刺激性排尿症状等,严重时可引起性功能障碍。组织学特点是多核、单核细胞在间质结缔组织中浸润。慢性前列腺炎的发病机制和诊断标准目前尚未明确,以致此病的研究受阻。动物模型可以帮助阐述慢性前列腺炎和慢性骨盆疼痛综合征的发病机制。本文就近年来啮齿类动物模型在此病研究中的优势和局限性进行了综述。
Chronic prostatitis is a disease caused by a number of factors characterized by perineal discomfort, pelvic pain, irrita- tive urination symptoms and even sexual dysfunction, and histologically with infiltration of poly-and mononuclear cells in the interstitial connective tissue. Research on this disease has somewhat been hindered, for its pathogenesis and diagnostic criteria are not yet clear. Animal models can help to explain the pathogenesis of chronic prostatitis and chronic pelvic pain syndrome. This article presents an o- verview on the advantages and limitations of rodent models in the studies of this disease.
出处
《中华男科学杂志》
CAS
CSCD
2013年第12期1124-1128,共5页
National Journal of Andrology
基金
江苏省自然科学基金(BK2011660)
江苏省科技厅省级科技专项(BM2013058)~~
