摘要
目的:观察麒麟丸联合左氧氟沙星治疗伴有附属性腺感染的弱精子症的疗效。方法:将伴有附属性腺感染的弱精子症患者80例随机分为两组,每组40例患者。1号组患者口服麒麟丸和左氧氟沙星,2号组患者口服左氧氟沙星。每组治疗1个疗程:麒麟丸用法为每次6 g,3次/d,服用30 d;左氧氟沙星用法为每次0.5 g,1次/d,服用20 d。每组在治疗前和治疗1个疗程后做精液分析,以前向运动精子百分率和精液中过氧化物酶阳性的白细胞数为主要疗效指标,评价治疗效果。结果:入选患者均完成了1个疗程的治疗。两个治疗组在治疗后,组1和组2前向运动精子百分率的治疗有效率分别为60%和17.5%,而且差异有统计学意义(P<0.05);精液中过氧化物酶阳性的白细胞数的治疗有效率分别为87.5%和82.5%,差异没有统计学意义(P>0.05)。结论:治疗伴有附属性腺感染的弱精子症,麒麟丸联合左氧氟沙星可以明显提高精子活动力,而且比单独应用左氧氟沙星具有更好的疗效,未见明显不良反应。
Objective ： To observe the efficacy of the combination of Qilin Pills and levofloxacin in the treatment of asthenosper- mia accompanied with accessory sex gland infection. Methods： We randomly assigned 80 asthenospermia patients with accessory sex gland infection to groups 1 and 2 of equal number, the former treated with Qilin Pills ＋ levofloxacin, and the latter with levofloxacin only. Qilin Pills were administered at the dose of 6 g rid for 30 days, and levofloxacin at the dose of 0.5g qd for 20 days. We obtained semen parameters, including the percentage of progressively motile sperm and peroxidase-positive white blood cell （WBC） count, be- fore and after medication, and compared the clinical effects between the two groups. Results ： All the patients accomplished the clinical trial. The therapeutic effectiveness rates in improving progressive sperm motility were 60% in group 1 and 17.5% in group 2, with statistically significant differences between the two groups （ P 〈 0.05 ）. As for the peroxidase-positive WBC count in semen, the effec- tiveness rates were 87.5% and 82.5% , respectively, with no significant differences between the two groups （P 〉 0.05 ）. Conclu- sion ： For the treatment of asthenospermia accompanied with accessory sex gland infection, Qilin Pills combined with levofloxacin is evi- dently better than levofloxacin alone in improving sperm motility, and it has no obvious adverse effects.
出处
《中华男科学杂志》
CAS
CSCD
2013年第12期1115-1118,共4页
National Journal of Andrology
基金
国家自然科学基金(81270696
81070488
81172432
81302223)
教育部高等学校博士学科点专项科研基金(20100171110060)
广东省自然科学基金重点项目(10251008901000005)
广东省科技计划项目(2011B031800115)~~
关键词
弱精子症
附属性腺感染
不育
麒麟丸
左氧氟沙星
asthenospermia
accessory sex gland infection
infertility
Qilin Pills
levofloxacin
