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噁二唑硫醚基型6-取代吲哚衍生物的合成和抗菌活性研究

Synthesis and antibacterial activities of 6-substituted indole derivatives containing oxadiazole and sulfide units
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摘要 以6-吲哚甲酸甲酯为起始原料,高产率的合成了9个新的含噁二唑硫醚基结构的6-吲哚衍生物,其结构均经核磁,质谱,红外光谱和元素分析确证.抗菌活性实验表明,所合成的目标物对大肠杆菌(E.coli)具有较好的抗菌活性. A new type of 6-indole derivatives containing oxadiazole and sulfide units are synthesized in good yields by using methyl indole-6-carboxylate as starting material. The structures of the new compounds are characterized by IH NMR, MS, IR and elemental analysis. The antibacterial activities are investigated against E. coli and S. aureus bacteria. The results indicate that these compounds have good antibacterial effects for E. coli.
出处 《西南民族大学学报(自然科学版)》 CAS 2013年第6期877-880,共4页 Journal of Southwest Minzu University(Natural Science Edition)
基金 四川省应用基础研究项目(No.2012 JY0028)
关键词 6-吲哚甲酸甲酯 (口恶)二唑 抑菌活性 methyl indole-6-carboxylate oxadiazole inhibitive activity
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  • 1ZHANG D T, WANG G T, ZHAO G L, et al. Synthesis and cytotoxic activity of novel 3-(1H-indole-3-yl)-IH-pyrazole-5- carbohydrazide derivatives[J]. E J Med Chem, 2011,46: 5868-5877. 被引量:1
  • 2TIWARI R K, VERMA A K, CHHILLAR A K, et a1. Synthesis and antifungal activity of substituted-Iu-methyl-lZ, 3,4-tetrahydropyrazinol[I ,2-a]indoles[J]. Bioorg Med Chern, 2006, 14: 2747-2752. 被引量:1
  • 3LEBOHO T C MICHAEL J P, OTTERLO W A, et at. The synthesis of 2- and 3-aryl indoles and 1,3.4.5-tetrahydropyrano[4,}-b] indoles and their antibacterial and antifungal activity[J]. Bioorg Med Chern Lett, 2009, 19: 4948-4951. 被引量:1
  • 4SINGH P, KAUR M, VERMA P. Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-identification of highly promising leads[J]. Bioorg Med Chern Lett, 2009, 19: 3054-3058. 被引量:1
  • 5AGARWAL A. SRIVASTAVA K, PURl S K, et at. Synthesis of substituted indole derivatives as a new class of antimalarial agents[J]. Bioorg Med Chern Lett, 2005, 15: 3133-3136. 被引量:1
  • 6VIGORITA M G, OTTANA R, ZAPPALA C. 2-(4-Pyridyl)-.6. 2 - I ,3,4-oxadiazolines from isonicotinoylhydrazones and dlazomethane as potential anti mycobacterial and anti-HIV agents[J]. IL Farmaco, 1995,50: 783-786. 被引量:1
  • 7叶英,赵志刚,刘兴利,李清寒.吲哚-6-酰腙类化合物的微波合成及其抗菌活性研究[J].有机化学,2009,29(6):993-997. 被引量:25
  • 8LI Y L. Clinical Microbiology and Inspection[M]. Beijing: People's Health Press, 1995. 被引量:1

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