摘要
在微波辐射条件下，以吲哚-6-甲酸甲酯为原料，设计合成了8个含l，2、4-三唑结构单元的希夫碱型吲哚衍生物通过微波法和常规法的研究对比发现，使用微波法后，产率从54％～72％提高到75％～92％，反应时间从80～120分钟缩短到8～10分钟．所有化合物的结构经1HNMR，IR，ESI-MS及元素分析确证．初步的抗菌活性表明，化合物5b和5c分别对大肠杆菌和金黄色葡萄球菌有一定的抑制作用．
Eight novel indole derivatives containing 1,2,4-triazole Schiff base units are efficiently synthesized via a method employing microwave irradiation by using Methyl indole-6-carboxylate as starting material. Compared with a conventional method, the yields are increased from 54% - 72% to 75% - 92% and the reaction times are reduced from 80 - 120 rain to 8 -10 min. The structures of these novel molecular tweezers are characterized by 1H NMR, IR, ESI-MS spectra and elemental analysis. The preliminary bioassay test indicates that compounds 5b and 5c exhibit inhibitory activity against Escherichia coil and Staphylococcus aureus
出处
《西南民族大学学报（自然科学版）》
CAS
2014年第1期44-48,共5页
Journal of Southwest Minzu University(Natural Science Edition)
基金
四川省应用基础研究项目(No.2012JY0028)
国家外专局外国文教专家项目(No.2012-13)
关键词
1
2
4-三唑
吲哚
微波合成
抗菌活性
1,2,4-triazole
indole
microwave synthesis
inhibitory activity
