摘要
目的探讨滤泡树突状细胞肉瘤的临床病理特点及鉴别诊断。方法运用组织病理学、免疫组织化学染色,回顾性分析2例滤泡树突状细胞肉瘤的特点,并结合相关文献进行讨论。结果 2例分别发生于颈部及腹股沟,瘤组织HE镜检为梭形或卵圆形肿瘤细胞,呈结节状浸润性生长方式,瘤细胞胞质丰富、嗜酸,合体状,呈片束状、编织状或旋涡状结构,有多少不等的淋巴细胞浸润。免疫组化示瘤细胞特异性表达CD21、CD35,部分表达的抗体有EMA、CD68、CD34、S100。结论滤泡树突状细胞肉瘤是一种少见的梭形或卵圆形细胞肿瘤,恶性度较低,结节状生长方式及淋巴细胞浸润对诊断可能有提示意义,CD21及CD35的表达对其确诊有重要意义。
Objective To investigate the clinical pathological features and itsantidiastole of follicular dendtrtic cell sarcoma. Methods Retrospectively analyse the pathological features of 2cases of follicular dendtrtic cell sarcoma with Immunohistochemical method and Histopathological staining method, and make a discussion based onrelatedliteratures. Results The 2 cases of sarcoma generatedat neck and groin respectively. The tissues of follicular dendtrtic cell sarcoma was observed under the light microscope after HemateinEosinstaining. It was found that the cells in the sarcoma present spindle or oval, and invasive growth, asin a nodular. The cells were abundant in cyctoplasm and acidophilus, and present in different appearance such as spiral, and had lymphocytic infihrationmore or less. Results of immunohisto-chemical staining prompt that CD21 and CD35 werespecifically expressed in cells from the sarcoma. Some antibodies, such as EMA/CD68/CD34/S100, were partially expressed. Conclusions Follicular dendtrtic cell sarcoma is a kind of rare spindle or oval tumor with low malignancy. The nodular growth way and lymphocytic infiltrates may prompt the diagnosis of follicular dendtrtic cell sarcoma. And the expression of CD21 and CD35 has great significance help for the definite diagnosis of follicular dendtrtic cell sarcoma.
出处
《齐齐哈尔医学院学报》
2013年第21期3133-3135,共3页
Journal of Qiqihar Medical University
关键词
滤泡树突状细胞肉瘤
病理特征
免疫组织化学
鉴别诊断
Follicular dendtrtic cell sarcoma
Pathological features
Immunohistochemistry
Differtial diagnosis
