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自体血清滴眼液在角膜病中的应用疗效研究 被引量:4

Application of Autologous Serum Eye Drops for Cornea Disorders
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摘要 目的:评估自体血清在治疗角膜病变中的疗效。方法:非随机选用眼科门诊及住院病例21例30眼,初查患者时连续三次细菌培养结果阴性给予局部自体血清治疗,根据角膜病变性质,局部适当给予抗生素,定期检查或询问疼痛缓解情况、眼部改变及眼部并发症。自体血清使用时间(3~60)天,平均(31.2±4.1)天。结果:21例30眼中治愈ll眼(36.7%),好转13眼(43.3%),无效5眼(20.0%)。难治性角膜上皮糜烂治愈3眼(50.0%),l眼好转(16.7%),2眼无效(33.3%);复发性角膜上皮剥脱治愈4眼(66.7%),好转2眼(33.3%);眼部化学伤治愈1眼(16.7%),好转2眼(33.3%),无效3眼(50.0%:1.眼部热灼伤治愈2眼(100%);神经营养学角膜溃疡治愈l眼(33.3%),好转2眼(66.7%);重症干眼好转6眼(85.7%),无效l眼(14.3%)。结论:自体血清滴眼液对于多种角膜病具有保护眼表、促进角膜愈合、降低角膜病复发等显著疗效。 Objective:To evaluate the effectiveness of autoogous serum eye drops for treatment of cornea disor ders. Methods:A total of 21 patients (30 eyes) were coUected. A descriptive prospective observational study car tied out from 2011 to 2012 that included patients with severs cornea epithelial erosion and denudation, cornea ul cer, ocular chemical burn, so on. All patients used autologous serum eye drops for (3 - 60)d. Treatment effective ness was evaluated by using a clinical examination and consultation in order to assess symptoms experienced by pa tients at the beginning and end of treatment. Results: 11 of 30 eyes were cured (36.7 % ), ineffective and improve ment was 20% (5 eyes) and 43.3% ( 13 eyes), respectively. Conclusions:The treatment with autologous serum eye drops improved ocular symptoms for most patients, and there is a significant effectiveness for protection of cornea surface and improvement of corneal healing.
作者 吴敬
机构地区 青海省人民医院
出处 《青海医药杂志》 2013年第6期1-3,共3页 Qinghai Medical Journal
关键词 血清滴眼液角膜病疗效 Cornea disorder Autologous serum eye drop Treatment
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参考文献9

  • 1Tsubota K, Goto E, Shimmura S, et al. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology, 1999,106 (10) : 1 984 - 1 989. 被引量:1
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二级参考文献13

  • 1曲忻,郝继龙.自体血清在眼表疾病治疗中的价值[J].中国实用眼科杂志,2005,23(10):1011-1014. 被引量:46
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  • 3Geerling G,Unterlauft JD,Kasper K, et al . Autologous serum and altern tive blood products for the treatment of ocular surface disorders. Opthalmology 2008;105(7):623-631. 被引量:1
  • 4Liu L, Hartwig D, Harloff S, et al. An optimised protocol for the production autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol 2005;243(7):706-714. 被引量:1
  • 5Quinto GG,Campos M, Behrens A. Autologous serum for ocular diseases. Arq Bras Oftalmol 2008;71(6 supl):47-54. 被引量:1
  • 6Matsumoto Y,Dogru M,Goto E, et al . Autologous serum application in the treatment of neurotrophic keratopathy. Opthalmology 2004;111(6):1115-1120. 被引量:1
  • 7Geerling G,Maclennan S,Hartwig D, et al. Autologous serum eye drops for ocular surface disorders. Br J Opthalmol 2004;88(11):1467-1474. 被引量:1
  • 8YoungAL,Cheng ACO,Ng HK, et al . The use of autologous serum in persistent corneal epithelial defects. Eye 2004;18(6):609-614. 被引量:1
  • 9PoonAC,Geerling G,Dart JK, et al. Autologous serum eyedrops for dry eyes and epithelial defects:clinical and in vitro toxcity studies. Br J Opthalmol 2001;85(10):1188-1197. 被引量:1
  • 10JengBH,Dupps WJ Jr.Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects. Cornea 2009;28(10):1104-1108. 被引量:1

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