摘要
目的：研究环孢霉素A在治疗重症干眼中的作用。方法：52例（104眼）重症干眼患者随机分为加0．5g／L环孢霉素A点眼实验组26例（52眼）和单纯用人工泪液点眼对照组26例（52眼），治疗3mo后测其泪液分泌试验、泪膜破裂时间、泪河弯曲面的曲率半径、泪膜干涉成像级别，并作对比。结果：泪液分泌试验改善了3～5mm：实验组的有效率为80．8％，对照组为23．1％；泪膜破裂时间延长3～5s：实验组的有效率为76．9％，对照组为19．2％；泪河弯曲面的曲率半径〉0．2mm：实验组的有效率为65．4％，对照组为11．5％；泪膜干涉成像级别〉Ⅲ级：实验组有效率为57．7％，对照组为11．5％。实验组与对照组之间的差异具有统计学意义（P〈0．01）。结论：环孢霉素A在治疗重症干眼中起着非常重要的作用，具有良好的治疗效果。
AIM ： To investigate the effect of cyclosporin A （CSA） in the treatment of severe dry eye syndrome.
METHODS： Fifty-two cases （104 eyes） of severe dry eye syndrome were randomly divided into two groups： the control group （52 eyes） only treated by artificial tears and the trial group （52 eyes） received artificial tears added 0.5g/L cyclosporin A. After three months＇ treatment, each case was examined by Schirmer test, tear break-up time （BUT） tear meniscus radius of curvature, tear film interferometry and the results were compared with those before the treatment.
RESULTS： The result of Schirmer＇s test had improved by 3-5mm. the efficiency of the trial group was 80.8% and that of the control group was 23.1% ; the result of the tear break-up time （BUT） had prolonged for 3-5 seconds： the efficiency of the trial group was 76.9% and the control one was 19. 2%; tear meniscus radius of curvature had improved by 0.2mm ： the efficiency of the trial group was 65.4% and the control was 11. 5%; that of tear film interferometry had improved for 3 grades： the trial group efficiency was 57. 7% and the control was 11. 5%. The differences of all the examination results for dry eye between CSA group and control group had statistical significance （ P〈 0.01 ） by χ^2 test.
CONCLUSION： Cyclosporin A （CSA） is obviously effective and has a satisfactory clinical therapeutic effect in the treatment of severe dry eye syndrome.
出处
《国际眼科杂志》
CAS
2009年第2期389-390,共2页
International Eye Science
