摘要
目的探讨2型糖尿病(T2DM)患者CA72-4水平和代谢状况的相关性。方法以320例经临床确诊的T2DM患者和同期年龄、性别、体重指数相匹配的379例健康对照为研究对象。检查项目包括CA72-4、空腹血糖(FPG)、糖化血红蛋白HbA1c和血脂等。分析糖尿病患者CA72-4水平与代谢状况、微血管病变和治疗方式的相关性。结果T2DM组和对照组CA72-4水平分别为3.6(2.9～4.4)U/ml和3.4(2.7～4.3)U/ml,两者差异无统计学意义。T2DM患者CA72-4水平与年龄、性别、病程、体重指数、空腹血糖、HbA1c、血脂、微血管病变和治疗方式无相关性。结论 CA72-4水平与T2DM无相关性。T2DM患者CA72-4水平升高,应考虑别的良性或恶性疾病。
Objective To discuss the correlation ot CA 72 - 4 levels and metabohc status in patients with type Z diabetes melh- tus （T2DM）. Methods Three hundred and twenty T2DM patients （female/male = 128/192） and three hundred seventy - nine healthy controls （female/male = 149/230） were included in the study. HbA1 c, fasting glucose, serum lipids were meas- ured in all participants. Then the correlation between CA 72 - 4 level and metabolic status, microantiopathy and therapy method were analyzed. Results CA72 - 4 level was 3.6 （2.9 - 4.4） U/mL in the 3-2DM group and 3.4 （ 2.7 - 4.3 ） U/mL in the control group （P 〉 0.05）, and the difference had no statistical significance. There was no association between CA72 -4 levels and age and sex of the patients, duration of diabetes, body mass index, metabolic control （ the levels of HbAlc, fasting plasma glucose, serum lipids）, microvascular complications （retinopathy, nephropathy, neuropathy） or treatment modalities. Conclu- sion CA 72 -4 levels had no correlation with T2DM. Increased CA 72 -4 levels in T2DM should be considered as the pres- ence of benign and malign conditions that could result in CA72 -4 elevation.
出处
《中国卫生检验杂志》
北大核心
2013年第16期3250-3252,共3页
Chinese Journal of Health Laboratory Technology
基金
浙江宁波市医学科技计划项目(2009B01)
关键词
2型糖尿病
CA72—4水平
微血管并发症
代谢状况
Type 2 diabetes mellitus
Carbohydrate antigen72 - 4
Microvascular complications
Metabolic control
