摘要
目的通过对500例自身免疫性疾病患者血清中抗核抗体谱检测结果的分析，了解自身免疫性疾病的分布特点，探讨抗核抗体谱联合临床血液学检测对自身免疫性疾病诊断的意义。方法采用欧盟线性免疫印迹法对500例自身免疫性疾病患者血清做抗核抗体谱检测，并进行常规临床血液学检测。结果在500例样本中，分别视疾病不同而有1项～5项不同抗体阳性的为80例。年龄12岁～83岁，女性57例，平均年龄52岁。其中类风湿关节炎（RA）患者17例（21．3％），重症肌无力（MG）13例（16．3％）、慢性肾小球肾炎（CNG）9例（11．3％）、2型糖尿病（T2DM）8例（10％）。检测ANA-LIA阳性的同时，根据其临床血液学检测指标进行分组。结论抗核抗体谱检测能对自身免疫性疾病有一定的提示性诊断作用，若将其与临床血液学检测指标联合起来则更有益于疾病的确诊。
Objective To understand the distribution characteristics of autoimmune diseases and explore the combined diagnostic value of antinuclear antibody spectrum with clinical hematology detection in the diagnosis of autoimmune diseases by analyzing antinuclear antibody spectrum - testing results of 500 cases with autoimmune diseases. Methods The linear immunoblot method was used to detect antinuelear antibody spectrum in 500 patients with autoimrnune disease, and routine clinical hematology detection was also performed. Results In 500 samples, 80 cases were detected 1 - 5 kinds of positive antibody, depending on the different diseases. These cases were between 12 and 83 years old with an average age of 52, including 57 women cases.Among the 80 cases, there were 17 rheumatoid arthritis（RA） cases （21.3%）, which is the most popular, 13 myasthenia gravis （MG） cases （ 16.3% ） , 9 chronic glomerulonephritis （CNG） cases （ 11.3% ） and 8 type 2 diabetes mellitus （T2DM） cases （ 10% ）. The ANA - LIA detection was combined with clinical hematology detection indicators to group these these 80 cases. Conclusion Antinuelear antibody spectrum detection is informative for diagnosis of autoimmune disease. Combining antinuclear antibody spectrum with clinical hematology detection is more conducive to the diagnosis of the disease.
出处
《中国卫生检验杂志》
北大核心
2013年第15期3128-3130,共3页
Chinese Journal of Health Laboratory Technology
