摘要
目的:探讨沙利度胺与蒲黄粉联合应用治疗糜烂型口腔扁平苔藓(erosive oral lichen planus,EOLP)的临床疗效。方法:90例EOLP患者随机平均分为2组。治疗组采用蜂蜜调和蒲黄粉局部敷用和口服沙利度胺片剂,对照组采用病损区黏膜下局部注射曲安奈德治疗,每周注射1次,整个研究为期8周。分别比较2组疗效,同时测定治疗前后TNF-α、IL-6、血清免疫球蛋白水平;治疗后6个月对2组患者进行随访。结果:治疗8周后,治疗组与对照组有效率分别为91.11%和75.56%(χ2=3.92,P<0.05);6个月后随访发现对照组和治疗组复发率分别为46.67%和13.04%(χ2=3.92,P<0.05)。2组患者治疗后TNF-α、IL-6、血清免疫球蛋白水平较治疗前均降低(P<0.05);治疗组患者治疗8周后TNF-α、IL-6、血清免疫球蛋白水平与对照组相比较明显下降(P<0.05)。结论:沙利度胺联合蒲黄粉治疗EOLP疗效高、可降低该病的复发率低。
Objective：To evaluate the efficacy of thalidomide combined with puhuang powder in the treatment for erosive oral lichen planus（EOLP）.Methods：90 patients with EOLP were treated with thalidomide combined with puhuang powder（treatment group,n =45） or triamcinolone acetonide （control group,n =45） in a randomized clinical trial.Before and 8 weeks after treatment the clinical symptoms and the efficacy were observed,TNF-α,IL-6 and serum immune globulin were examined.6 months after treatment the recurrence rate was observed.Results：8 weeks after treatment the total effective rate of the treatment and control group was 86.12％ and 70.94％ respectively（P ＜0.01） ; 6 months after treatment the recurrence rate of the treatment and control group was 13.04％ and 46.67％ respectively（P ＜ 0.05）.In the two groups,after treatment TNF-α,IL-6 and serum immune globulin were decreased（P ＜ 0.05） ; those in treatment group were lower than in control group （P ＜ 0.05）.Conclusion：Thalidomide combined with puhuang powder is more effective than triamcinolone acetonide in treatment of EOLP,and may decrease the recurrence.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2013年第6期856-859,共4页
Journal of Practical Stomatology
