摘要
目的研究CD4+CD25+CD127 LOW/-调节性T细胞(Tregs)在类风湿关节炎患者(RA)外周血中的比例改变,并探讨其在疾病进程中的意义。方法选取活动期及稳定期RA患者,采用流式细胞术,检测外周血中CD4+CD25+CD127 LOW/-Treg细胞占CD4+细胞的比例,并与健康者进行比较。结果 RA患者CD4+CD25+细胞所占比例与健康对照组差异无统计学意义;而活动期患者外周血CD4+CD25+CD127 LOW/-Treg细胞明显低于稳定期组和健康对照组(P<0.05)。结论类风湿性关节炎活动期时CD4+CD25+CD127 LOW/-Treg细胞明显减少,这群调节性T细胞可能参与了类风湿性关节炎的疾病进程。
Objective To investigate the percentage and significance of CD4＋CD25＋CD127LOW/- regulatory T cells in peripheral blood in patients with rheumatoid arthritis. Methods Patients with active and non-active rheuma- toid arthritis were included in this study. The percentage of CD4＋CD25＋CD127LOW/- regulatory T cells in CD4＋ T cells were determined by four-colour flow cytometry and the results were compared with the normal. Results There was similar percentage of CD4＋ CD25＋T cells in peripheral blood of RA patients and healthy subjects. However,the percentage of CD4＋CD25＋CD127LOW/- regulatory T cells in active RA group was lower than that in non-active group and healthy subjects （P〈0.05）. Conclusion There was similar percentage of CD4＋ CD25＋ T cells in peripher- al blood of RA patients and healthy subjects. However, the percentage of CD4＋CD25＋CD127LOW/- regulatory T cells in active RA group was lower than that in non-active group and healthy subjects （P〈0.05）.
出处
《检验医学与临床》
CAS
2013年第22期2984-2985,2987,共3页
Laboratory Medicine and Clinic
