摘要
急性肾损伤是心脏外科手术后常见的严重并发症,发病率和病死率均较高.血肌酐及尿量作为急性肾损伤的标志物缺乏敏感性,延误了早期有效的治疗.近年来对于诊断急性肾损伤的生物学标志物方面的研究取得了较大进展,有些指标已逐步进入临床研究阶段,其中包括中性粒细胞明胶酶相关脂质运载蛋白、胱抑素C、肾损伤分子-1、白细胞介素-18等.本文旨在对心脏外科术后急性肾损伤早期生物学标志物基础及临床方面的研究进展作一综述.
Acute kidney injury （AKI） is a common and serious clinical syndrome after cardiac surgery with the high morbidity and mortality.As the markers of AKI,Serum creatinine and urine output is not sensitive for early detection.Due to the lack of early biomakers for AKI,early effective treatment has been delayed.Identification of novel biomarkers for AKI has progressed to the clinical phase.Novel biomakers include neutrophil gelatinase-associated lipocalin,kidney injury molecule-1,Cystatin C,IL-18,and so on.In this article the author will review the current progress of these clinical and experimental novel AKI biomarkers.
出处
《国际外科学杂志》
2013年第10期677-680,共4页
International Journal of Surgery
基金
南京市医学科技发展项目（No.YKK10091）
江苏省卫生厅科技项目（No.H201036）
