摘要
目的探讨各型老年期痴呆患者血浆同型半胱氨酸(Hcy)水平变化特点。方法采用放射免疫比浊法测定阿尔茨海默病(AD)42例、血管性痴呆(VD)40例、帕金森痴呆(PDD)33例及对照组50例,空腹血浆Hcy及血管紧张素转化酶水平。结果 PDD组血浆Hcy水平低于VD组、AD组、对照组(P<0.05),而血管紧张素转化酶水平高于VD组、AD组、对照组(P<0.05);VD组、AD组、对照组的Hcy水平及血管紧张素转化酶水平比较差异均无统计学意义(P>0.05)。结论可能血浆Hcy水平与稳定期老年性痴呆无关联。
Objective To investigate the changes of plasma homocysteine （ Hcy ） levels among patients with various types of dementia .Methods Fasting plasma Hcy and angiotensin converting enzyme levels were respectively measured in 42 patients with Alzheimer′s disease（AD）,40 patients with vascular dementia （VD）,33 patients with Parkinson′s dementia （ PDD ） and 50 cases of the control with immunoturbidimetry .Results The levels of plasma Hcy in PDD group were significantly lower than those in VD group ,AD group and the control（P〈0.05）,while the levels of angiotensin converting enzyme in PDD group were significantly higher than those in VD group ,AD group and the control（P〈0.05）.There was no significant difference in the Hcy and angiotensin converting enzyme levels a -mong AD group,VD group and the control（P〉0.05）.Conclusion The levels of plasma Hcy might not be associat-ed with senile dementia during the stable period .
出处
《广西医学》
CAS
2013年第11期1439-1441,1453,共4页
Guangxi Medical Journal
基金
科技部"重点新药创制"(十一五计划)<神经退行性疾病新药临床评价研究技术平台建设>项目(2008ZX09312-014)
