摘要
目的探讨不同海拔地区高原红细胞增多症(HAPC)患者体内同型半胱氨酸(Hcy)与氧自由基代谢水平的关系。方法在两个不同海拔地区(3 300 m、4 080 m)对79例HAPC患者和100例健康人进行了血清Hcy、氧自由基代谢指标丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的检测。结果海拔3 300m和4 080 m地区HAPC患者血液中Hcy、MDA、SOD及GSH-Px水平分别为:(20.5±5.7)μmol/L(、5.79±0.53)μmol/L(、1 007.5±138.4)U/(g.Hb)(、23.8±5.1)U/(g.Hb)vs(23.7±5.7)μmol/L、(6.04±0.67)μmol/L、(894.3±146.5)U/(g.Hb)(、21.5±4.2)U/(g.Hb)。在同一海拔条件下,HAPC患者血清Hcy、MDA含量均较健康对照组明显升高(P<0.01),红细胞SOD、GSH-Px活性显著降低(P<0.01);且随着海拔升高,HAPC患者血清Hcy、MDA含量明显增加(P<0.01),而红细胞SOD、GSH-Px活性显著降低(P<0.01);相关分析结果表明,血清Hcy与MDA含量呈明显正相关(r=0.948,P<0.01),与红细胞SOD、GSH-Px活性呈显著负相关(r=-0.986、-0.978,P<0.01)。结论血清Hcy水平升高与氧自由基代谢紊乱在HAPC发病过程中起着重要作用。
Objective To investigate the relationship between hyperhomocy （Hcy） and oxygen free radical metabolism in patients with high altitude polycythemia （HAPC） at different altitudes. Methods Serum Hcy, superoxide dismutase（SOD）, glutathionperoxide（GSH-Px） and malondialdehyde（MDA） level were measured in 79 cases patients with HAPC and 100 healthy cases at two different altitudes. Results In areas of 3 300 m and 4,080 m, serum Hcy, MDA, SOD and GSH- Px level of HAPC patients respectively （20. 5±5.7）μmol/L and （5. 79±0. 53） μmol/L and （1 007.5±138.4） U/（g · Hb） and （23.8±5.1） U/（g · Hb） with （23.7 ± 5.7） μmol/L and （6.04±0. 67） μmol/L and （894.3±146.5） U/（g · Hb） and （21.5±4. 2 U/（g·Hb）. At the same altitude, Hcy and MDA levels of HAPC patients were higher（ P 〈0. 01） and SOD and GSH-Px activities lower significantly than those of healthy controls（ P 〈0. 01）. Along with higher altitude, serum t-Icy and MDA levels of HAPC patients increased （P 〈. 0.01） and SOD and GSH-Px activities of RBC were lower（ P 〈0.01） in HAPC patients. Serum Hcy was positively correlated with MDA （ r = 0. 948, P 〈 0.01） and SOD and GSH-Px activities of RBC were negatively correlated （r =-0. 986 ,-0. 978, P 〈0.01）. Conclusion Serum HCY level increases with disturbed oxygen free radical metabolism,which plays an important role in the development of HAPC.
出处
《临床荟萃》
CAS
北大核心
2006年第5期322-324,共3页
Clinical Focus
