摘要
目的探讨血浆5-羟色胺（5-TH）与慢性阻塞性肺疾病（COPD）的关系。方法选择COPD患者65例，对照组为同期中老年健康体检者60例，所有研究对象进行常规肺功能测定，采用酶联免疫吸附试验法（ELISA）测定COPD组（包括急性发作期和稳定期）和对照组血浆5HT浓度。结果COPD组（急性加重期、稳定期）血浆5-HT水平较健康对照组显著升高（P〈0．01），而COPD急性加重期较稳定期，及COPD不同严重程度分级间血浆5-HT浓度差异均无统计学意义；〈65岁健康组，吸烟者及戒烟者血浆5-HT浓度显著高于非吸烟者（P〈0．05），≥65岁健康组戒烟者血浆5-HT浓度对比〈65岁健康对照组戒烟者显著降低（P＜0．05），COPD组无论是不同年龄段及吸烟状况，各组间5-TH浓度无差异；在有吸烟史的对照组和COPD组中吸烟指数与血浆5-HT浓度无明显相关性，对照组有吸烟史者年龄与血浆5-HT浓度呈负相关（r=-0．391，P=0．007）。结论在COPD炎症状态下，血浆5-HT浓度明显升高，吸烟、年龄等因素可能对其有一定影响，高水平的血浆5HT聚集在肺部血管系统内可能是诱导及加重COPD炎症反应的重要因素。
Objective To explore the role of plasma 5-HT in chronic obstructive pulmonary disease （COPD）. Methods Sixty-five COPD patients and sixty elderly healthy controls were collected. All the selected cases routinely measured the pulmonary function parameters, plasma 5-HT levels were detected in healthy control group by ELISA, and also obtained in COPD group respectively on the time of acut6 exacerbation and stable period. Results Plasma 5-HT levels of COPD group on the time of acute exacerbation and stable period were significantly higher than healthy control group （P〈0.01）. No significant difference in plasma 5-HT levels between the time of AECOPD and the COPD stable period, or across COPD severity. In healthy group〈65 years old, plasma 5-HT levels were significantly higher in current smokers or ex smokers than in non-smokers（ P〈0.05）. In healthy group, plasma 5-HT levels were significantly higher in ex-smokers≥65 years old than ex-smokers〈 65 years old （ P 〈0.05）. In COPD group across every age and smoking conditions There were no significant differences in plasma 5- HT levels. In ever-smokers （healthy group and COPD group）, there were no significant correlation between plasma 5-HT levels and smoking index. There were significant correlation between plasma 5-HT levels and age in healthy ever-smokers （ r =-0. 391, P = 0. 007）. Conclusions Plasma 5-HT levels are significantly higher in COPD group, Some factors such as cigarette smoke and age could produce some effects on 5 HT levels, high plasma 5-HT levels which accumulates in the pulmonary vasculature may play important roles in inducing and aggravating inflammatory reaction in COPD.
出处
《国际呼吸杂志》
2013年第21期1635-1638,共4页
International Journal of Respiration
关键词
血浆5-羟色胺
慢性阻塞性肺疾病
年龄
吸烟
Plasma 5-HT
Chronic obstructive pulmonary disease
Age
Cigarette smoke
