摘要
目的分析肿瘤医院患者痰液中分离的铜绿假单胞菌(PAE)耐药性,为PAE感染的肿瘤患者的治疗提供依据。方法采用WHONET 5.4软件回顾性分析肿瘤专科医院2007-2011年痰液标本中铜绿假单胞菌的检出率及耐药性。结果痰液标本中铜绿假单胞菌2007-2011年的分离率分别为15.5%、8.8%、13.6%、7.7%和7.4%;科室分布以放射治疗科最多,占37.7%,其次是ICU和化疗病房,分别占22.4%和11.1%;铜绿假单胞菌对阿米卡星最敏感,对头孢曲松耐药率极高,5年中,亚胺培南、妥布霉素、头孢吡肟、庆大霉素和头孢哌酮/舒巴坦均于2009年耐药性达到最高,后逐渐下降,左氧氟沙星和环丙沙星的耐药性则呈波动显现,但在2010年有明显下降。结论及时监控和掌握肿瘤患者痰液中铜绿假单胞菌的耐药特点,是合理使用抗菌药物、控制和减少多耐药性铜绿假单胞菌感染的关键。
OBJECTIVE To analyze the drug resistance of Pseudomonas aeruginosa isolated from sputum of tumor patients so as to provide guidance for the treatment of P. aeruginosa infections in the tumor patients. METHODS The detection rate and the drug resistance of P. aeruginosa isolated from sputum specimens obtained from the tumor hospital from 2007 to 2011 were retrospectively analyzed by WHONET 5. 4 software. RESULTS The isolation rate of P. aeruginosa isolated from sputum specimens was 15.5% in 2007, 8. 8% in 2008, 13.6% in 2009,7. 7% in 2010, and 7. 4% in 2011. As for the distribution of the departments, the proportion of the department of radiation oncology was the largest （37.7 %）, followed by ICU （22.4 %） and ehemotheraphy ward （11. 1%）. The P. aeruginosa strains were most sensitive to amikacin, and＇ the drug resistance rate of P. aeruginosa to ceftriaxone was particularly high; during the past five years, the drug resistane~ rates to imipenem,tobramycin, cefepime, gentamicin and eefoperazone-sulbactam reached to the peak in 2009 and then declined; the drug resistance rates to levofloxacin and eiprofloxacin showed a significantly fluctuated trend and declined obviously in 2010. CONCLUSION The timely monitoring of drug resistance of P. aeruginosa isolated from the sputum specimens of the tumor patients is the key to reasonably use antibiotics and reduce the incidence of multidrug-resistant P. aeruginosa infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第22期5556-5558,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81272067)
关键词
痰液
肿瘤患者
铜绿假单胞菌
耐药性
Sputum
Tumor patient
Pseudomonas aeruginosa
Drug resistance
