摘要
目的探讨孕产妇阴道微生态的变化及相关影响因素，为临床预防和控制孕产妇菌群失衡提供依据。方法选择2012年1—12月在医院就诊的妊娠组孕妇和产后组产妇各400例，采用用pH1．8～9．0拭纸进行阴道测定，对阴道菌群的密集度、多样性、优势菌、炎症反应等进行微生态检测，用放射免疫法测定激素水平。结果产后组菌群临界阳性率为45．25％，低于妊娠组的53．75％（P〈0．05）；产后组细菌性阴道病发生率为43．00％，高于妊娠组的19．75％（P〈0．05）；产后组检出乳杆菌数量0及〈1个分别占11．75％及24．75％，均高于妊娠组（P〈0．05）；产后组检出乳杆菌数量1～4及5～30个分别占9．50％及6．50％，均低于妊娠组（P〈O．05）；产后组pH值为6．22土1．13，高于妊娠组的5．59±1．07（P〈0．05）；产后组H2O2、LE和唾液酸苷酶阳性率分别为50．75％、31．15％和28．00％，均高于妊娠组（P〈0．05）；产后组卵泡生成激素、催乳激素、孕酮和雌二醇分别为（9．18±1．95）U／L、（1718．28±184．05）U／L、（2．57±0．49）mmol／L和（1068．54±171．61）pmol／L，与妊娠组比较，差异有统计学意义（P〈0．05）。结论产后妇女雌激素水平较孕期降低，阴道乳杆菌数量减少、pH值升高、微生态变化较大，导致细菌性阴道病发病率增高。
OBJECTIVE To explore the change of vaginal microecosystem of the pregnant women and the related influencing factors so as to provide bases for the prevention and control of flora imbalance. METHODS Totally 400 pregnant women （the pregnancy group） and 400 pregnant women （the delivery group）, who were treated in the hospital from Jan to Dec 2012, were enrolled in the study, then the vaginal examination was performed with pH dipstick, the microecosystem test was carried out for the density of vaginal flora, diversity, dominant species, and inflammatory reactions, and the hormone level was determined with the use of radioimmunoassay. RESULTS The positive rate of the flora critical value of the delivery group was 11.75%, lower than 53.75% of the pregnancy group（P〈0.05）; the incidence rate of the bacterial vaginosis of the delivery group was 43.00%, higher than 19.75% of the pregnancy group（P〈0. 05）% the detection rates of the Lactobacilli 0 and more than 1 were respectively 11.75% and 24.75%, higher than those of the pregnancy group （P〈0.05） ; the detection rates of the Lactobacilli varying from 1 to 4 and from 5 to 30 were respectively 9.50% and 6.50%, lower than those of the pregnancy group（P〈0.05）; the p H value of the delivery group was （6.22±1. 13）, higher than （5. 59±1.07） of the pregnancy group （P〈 0. 05）% the positive rates of the H202, LE, and neuraminidase were respectively 50.75%, 31. 15%, and 28. 00%, higher than those of the pregnancy group; the levels of follicle stimulating hormone, prolactin, progesterone, and estradiol were respectively （9. 18±1. 95） U/L, （1718. 28±184.05）U/L, （2.5±0.49）mmol/L, and （1068.54±171.61）pmol/L, as compared with the pregnancy group, the differences were statistically significant（P〈0.05）. CONCLUSION As compared with the gestational pregnant women, the postpartum women have lower level of estrogen, with the number of Lactobacillus decreased, pH value elevated, change of microecosystem significant, which
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第22期5468-5470,共3页
Chinese Journal of Nosocomiology
基金
贵州省科技厅基金项目(默科合字[2011]037)
关键词
孕妇
产妇
微生态
乳杆菌
Pregnant women
Puerpera
Microecosystem
Lactobacillus
