摘要
目的:制备槲皮素微乳,并对其性质进行考察。方法:采用HPLC法测定槲皮素在不同油相、表面活性剂和助表面活性剂中的溶解度,初步筛选处方组成,通过绘制伪三元相图对处方进行优化;并初步考察槲皮素微乳的黏度、粒径及其分布和稳定性。结果:槲皮素微乳制备的最优处方为槲皮素-油酸乙酯-聚山梨醇酯80-1,2-丙二醇-水的质量比为2.5∶4∶27∶9∶60;自制微乳澄清透明,平均粒径为(51.8±9.3)nm,多分散系数为0.265±0.008,3 000 rpm离心15 min后无分层现象。结论:通过优化处方制备的槲皮素微乳理化性质稳定,能够提高药物的溶解度。
OBJECrlVE To prepare quercetin microemulsion and to investigate its physicochemical properties. METHODS The solubilities of quercetin in different oils, surfactants and co-surfactants were determined by HPLC method. The formula- tion was optimizated by pseudoternary phase diagram. The viscosity, particle diameter with its distribution and stability of quercetin microemulsion were investigated. RESULTS The optimized formulation was as follows： the proportion of quercetin~ ethyl oleate - Tween-80-1,2-propanediol water was 2.5：4：27：9：60. The emulsion was transparent. The average particle diame- ter of quercetin microemulsion was （51.8 ＋ 9. 3） nm with a polydispersity index of 0. 265 ＋ 0. 008, and there was no any layered after centrifuging at 3000 rpm for 15 rain. CONCLUSION By optimized microemulsion formulation, the prepared quercetin mi- croemulsion possesses stable physical and chemical properties,it could be increase the solubility of quercetin.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第20期1685-1689,共5页
Chinese Journal of Hospital Pharmacy
基金
陕西省教育厅科研计划项目(No.12JK1024)
关键词
槲皮素
微乳
伪三元相图
quercetin
microemulsion
pseudoternary phase diagram
