摘要
目的:建立速效止泻胶囊体外溶出度测定方法,考察其体外溶出规律。方法:采用高效液相色谱(HPLC),检测波长256 nm,溶出介质为0.1 mol·L-1HCl,转速120 r·min-1,浆法(沉降蓝)。结果:速效止泻胶囊溶出率的均一性和重复性良好,以45 min为取样时间,盐酸小檗碱溶出率不少于75%为限度。结论:方法简单、准确、可靠,可用于速效止泻胶囊溶出度的测定。
Objective：This manuscript presents a method to research the dissolution and external leaching rule of Suxiao Zhixie capsule.Method：By using of HPLC method,the wavelength of the spectrophotometer set at 256 nm.The dissolution medium is 0.1 mol · L-1 HC1,the rotate speed is 120 r · min-1 （settlement basket method）.Result：We get a good uniform and repeatability during assaying the dissolution of Suxiao Zhixie capsule.The sampling time should be 45 min,and the percentage of dissolution should not less than 75％.Conclusion：The method we used to assay the dissolution of Suxiao Zhixie capsule is simple,accuracy and reliable.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第20期108-111,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81102815)
教育部博士点新教师基金(20110013120017)
关键词
速效止泻胶囊
溶出度
高效液相色谱
浆法
Suxiao Zhixie capsule
dissolution
HPLC
settlement basket method
