摘要
目的观察注射用核糖核酸Ⅱ胸内注入治疗恶性胸腔积液的疗效及其对机体免疫功能的影响。方法收集2012年3月至2013年2月本院经病理和（或）细胞学确诊的晚期肺部肿瘤所至的恶性胸腔积液的患者63例，经胸腔穿刺抽液或胸腔闭式引流后即时注入注射用核糖核酸Ⅱ300mg，治疗I周胸部X线显示如仍有胸腔积液再引流后重复给药1次。4周后按WHO规定的临床疗效评定标准，观察注射用核糖核酸Ⅱ的恶性胸腔积液控制疗效，并应用流式细胞仪对比治疗前后（注药前和注药后1周）患者外周血T淋巴细胞的变化情况。结果注射用核糖核酸Ⅱ胸腔内注入疗法的总体有效率达90．48％，其中完全缓解（CR）30例（47．62％），部分缓解（PR）14例（22．22％），稳定（SR）13例（20．63％），无效6例。治疗后外周血T淋巴细胞亚群中的CD3＋、CD4＋水平和CD4＋/CD8＋值较治疗前升高（CD3＋：67．49±6．41比64．21±4．87，CD4＋：28．72±3．85比24．59±3．47，CD4＋／CD8＋：0．91±0．07比0．65±0．04，均（P〈0．05），CD8＋水平明显下降（33．96±5．86比38．16±4．89，P〈0．05）。结论注射用核糖核酸Ⅱ胸腔内注入疗法治疗恶性胸腔积液的疗效确切，能明显改善机体状况和增强免疫功能。
Objective To determine the efficacy of ribonueleic acid Ⅱ （RNA Ⅱ ） intrathoracie injection on malignant pleural effusion and the host immunity. Methods Sixty-three patients with pathology- and （or） cytology-diagnosed malignant pleural effusion admitted to The First Affiliated Hospital, Sun Yat sen University between March 2012 and February 2013 were subjected to RNA （300 rag, once weekly） injection via thoracocentesis or thoracic cavity closed drainage. Repetitive administration was performed in case of pleural effusion as suggested by chest X-ray at week 1. The therapeutic outcomes were assessed based on the WHO criteria. The changes in peripheral blood T ceils was assessed using flow cytometry prior to and following one week after the treatment. Results The RNA ntrathoracic injection yielded an overall effective rate of 90.48% , consisting of 30 cases with complete remission （CR, 47.62% ） , 14 partial remission （PR, 22.22% ） , 13 stability rate （SR, 20.63% ） and 6 inefficiency. Treatment with RNA II resulted in significantly increased levels of CD3＊ （ 67.49.±6.41 vs 64.21±4.87, P〈0.05）, CD4± cells （28.72± 3.85 vs 24.59.± 3.47, P〈0.05） and CDg±/CD8 ± ratio （0.91 ±0.07 vs 0.65 ±0.04, P〈0.05） , yet markedly reduced CDs cells （33.96±5.86 vs 38.16±4.89, P〈0.05）. Conclusion RNA 1I intrathoraeie injection has definite efficacy on malignant pleural effusion and can improve physical conditions and host immunity.
出处
《中华生物医学工程杂志》
CAS
2013年第3期230-232,共3页
Chinese Journal of Biomedical Engineering
关键词
核糖核酸Ⅱ
胸腔积液
恶性
化学疗法
癌
局部灌注
T淋巴细胞亚群
Ribonucleic acid Ⅱ
Pleural effusion, malignant
Chemotherapy, cancer,regional perfusion
T-lymphocyte subsets
