摘要
目的评价鸦胆子油乳联合化疗方案治疗中晚期非小细胞肺癌的临床疗效和副反应。方法将83例中晚期非小细胞肺癌患者随机分为两组,试验组的45例研究对象采用鸦胆子油乳联合TP方案化疗治疗,对照组的患者仅接受TP方案化疗。结果试验组和对照组的治疗有效率分别为57.8%和47.4%,差异无统计学意义(P=0.344)。试验组的贫血,白细胞减低,恶心呕吐的发生率显著低于对照组(P<0.05)。结论鸦胆子油乳的应用可显著减轻中晚期非小细胞肺癌患者化疗所引起的毒副反应,提高了患者的耐受性。
Objective To evaluate the clinical efficacy and adverse effects of brucea javanica oil emulsion combined with TP chemotherapy in treating advanced non-small-cell lung cancer. Methods Totally 83 patients with advanced non-small-cell lung cancer were divided into two groups randomly. 45 cases of test group were given brucea javanica oil supplemented with TP chemotherapy, and 38 patients of control group were treated with TP chemotherapy only. Results The overall response rates of test group and control group were 57.8 %. and 47.4% respectively, No significant difference was seen between two groups （X2 = 0. 896, P = 0. 344 ）. Compared with those in control group, patients in test group had significantly less adverse effects in anemia, neutropenia and vomiting （ P 〈 0. 05 ） Conclusion Brucea javanica oil emulsion can reduce the toxicity of anticancer drugs, and increase the tolerance of patients on chemotherapy.
出处
《临床肺科杂志》
2012年第10期1854-1855,共2页
Journal of Clinical Pulmonary Medicine
关键词
鸦胆子油乳
非小细胞肺癌
化疗
Brucea javanica oil
Non-small-cell lung cancer
Chemotherapy
