摘要
目的:探讨中国人群中DNA修复基因X线修复交叉互补因子3(X-ray cross-complementing group 3,XRCC3)241位点(XRCC3 Thr241Met)的基因多态性与肝细胞癌(hepatocellular carcinoma,HCC)遗传易感性的关联关系。方法:利用PubMed、EMBASE、万方数据库、中国期刊全文数据库及维普数据库检索国内外公开发表的关于XRCC3 Thr241Met的多态性与HCC关系的所有文献。采用Meta分析的方法合并所有纳入研究的优势比(odds ratios,ORs)值及其95%可信区间(confidence intervals,CIs)。根据人群分布地区及HBV慢性感染、吸烟暴露因素的不同进行亚组分析,并分析组间异质性的可能来源。结果:本文共纳入从2008~2012年发表的随机对照研究5篇,共计HCC患者1 741例,对照2 596例。①在中国人群中,XRCC3 Thr241Met的T等位基因及变异基因型与HCC的发生存在明显的相关性(OR T vs C=1.84,95%CI:1.19~2.85,POR=0.003;ORTT vs CC=4.71,95%CI:2.14~10.34,POR<0.001;ORCT vs CC.=1.59,95%CI:1.07~2.36,POR=0.022;ORTT vs CC+CT=4.21,95%CI:2.21~8.00,POR<0.001;ORCT+TT vs CC=1.83,95%CI:1.11~3.00,POR=0.017);②在广西人群中,携带XRCC3 Thr241Met的变异等位基因及基因型的个体,其HCC的易感性明显升高(OR T vs C=2.23,95%CI:1.32~3.77,POR=0.003;ORTT vs CC=5.74,95%CI:2.33~14.14,POR<0.001;ORCT vs CC=1.91,95%CI:1.23~2.99,POR=0.004;ORTT vs CC+CT=4.63,95%CI:2.20~9.76,POR<0.001;ORCT+TT vs CC=2.29,95%CI:1.26~4.18,POR=0.007);③未发现XRCC3 Thr241Met的基因多态性与HCC发病的2种危险因素HBV慢性感染、吸烟之间存在交互作用。结论:在中国人群尤其是广西人群中,XRCC3 Thr241Met的基因多态性与HCC的发病风险有关,但不存在基因与环境的交互作用。
Objective：To estimate the association between the XRCC3 Thr241Met polymorphism and hepatocellular carcinoma （HCC） risk. Methods：We performed a comprehensive search of the PubMed,EMBASE,Wanfang,China National Knowledge Infrastructure （CNKI） and Weipu databases for studies on the relationship of the XRCC3 Thr241Met polymorphism with HCC risk. The pooled odds ratios （ORs） with the corresponding 95% confidence intervals （95%Cis） were calculated in this meta-analysis. In addition, subgroup analyses by source of populations, HBV infection and smoking status were conducted for further estimation. The source of between-study heterogeneity was also evaluated. Results：Five eligible papers published from 2008 to 2012 with 1 741 HCC cases and 2 596 controls were finally included into the present meta-analysis. （1） Meta-analysis of total included studies in Chinese population showed that the XRCC3 Thr241Met polymorphism was significantly associated with an increased risk of HCC in all genetic contrast models （ORTssCC = 1.84,95%CI： 1.19~2.85,POR = 0.003;ORTrwCC = 4.71,95%CI：2.14~10.34,PoR 〈 0.001;ORcrCC = 1.59,95% CI： 1.07--2.36,PoR = 0.022;ORrr~, cc＋cr = 4.21,95%CI：2.21-8.00,PoR 〈 0.001 ;ORcr^Tr, cc =1.83,95%CI： 1.11-3.00,PoR = 0.017）. （3）Meta-analysis in Guangxi population suggested that individuals carrying the variants of XRCC3 Thr241Met were more susceptible to hepatocellular carcinoma （ ORT vs c = 2.23,95%CI： 1.32-3.77, POR = 0.003 ; ORTr vs cc=5.74, 95%CI ： 2.33-14.14, POR 〈 0.001 ; ORcr v, cc = 1.91,95%CI： 1.23--2.99,PoR = 0.004;ORTrw cc＋cr = 4.63,95%CI：2.20~9.76,POR 〈 0.001 ;ORTT CC =2.29,95%CI： 1.26-4.18,PoR = 0.007）. （3） In subgroup analyses by HBV infection and smoking status,no associations were found between the HBV infection and smoking status and HCC risk. Conclusion：The present recta-analysis suggested an important role of the XRCC3 Thr241Me polymor- phism in the risk of developing HCC in Chinese,especially in Guangxi population,but no
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第10期1478-1482,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省科教兴卫工程重点学科开放课题(LJ07200901)
