摘要
目的调查上海市普陀区变应性鼻炎（AR）患者的吸入性变应原特点，为AR的诊治提供临床参考。方法利用15种标准化皮肤点刺液对631例疑似AR的患者进行皮肤点刺试验（SPT），将诊断为AR的355例患者分为4个年龄段（3-17岁，18-39岁，40-59岁，≥60岁），分析致敏的变应原特点。结果屋尘螨和粉尘螨为最常见的变应原，阳性率分别为49．9％和49．8％；65．4％的AR患者对≥3种变应原过敏，18-39岁的AR患者对多种变应原过敏的比例最高（71．2％），≥60岁的AR患者对多种变应原过敏的比例最低（40．7％），差异有统计学意义（X^2=10．839，P=0．013）；粉尘螨和屋尘螨SPT结果呈正相关（rs〉0．600，P〈0．01）；粉尘螨和屋尘螨SPT反应程度与过敏的变应原种类数呈正相关（rs〉0．300，P〈0．05）。结论粉尘螨和屋尘螨是引起AR的重要致敏原，机体对尘螨过强的超敏反应可能会增加其他变应原致敏的风险。
Objective To investigate the characteristics of inhaled allergens in patients with allergic rhinitis （AR） from Shanghai Putuo District, and to provide clinical reference for the diagnosis and treatment of allergic rhinitis. Methods Fifteen kinds of standardized allergens prick liquid were used to perform skin prick test （SPT） on 631 patients who were suspected of allergic rhinitis. 355 patients were diagnosed as AR and were divided into four age groups （3 -17 years old, 18 -39 years old, 40 -59 years old, and ≥ 60 years old）. The characteristics of sensitized allergens was analyzed. Results Dermatophagoides pteronyssinus （ Der p） and Dermatophagoides farinae （ Der f） were the most common allergens, of which the positive rate was 49.9% and 49. 8% respectively. 65.4% of AR patients were sensitized to ≥3 allergens kinds. Of all age groups, the 18 -39 years old age group showed the highest proportion of multiple allergens sensitization （71.2%）, and the age ≥ 60 years old group showed the lowest proportion of multiple allergens sensitization （40.7%）, and the difference was significant （X^2 = 10. 839, P =0. 013）. The SPT results of Der f and Der p showed a positive correlation （rs 〉0. 600, P 〈0.01 ）. The SPT reaction degree of Der f and Der p was positively correlated with the number of sensitized allergen kinds （rs 〉 0. 300 ,P 〈 0. 05）. Conclusion Der f and Der p are the most common inhaled allergen kinds in AIR patients from Shanghai Putuo District. The body＇s excessive hypersensitivity to dust mites may increase the risk of other allergen sensitization .
出处
《安徽医科大学学报》
CAS
北大核心
2013年第11期1380-1383,共4页
Acta Universitatis Medicinalis Anhui
基金
上海市普陀区卫生系统自主创新资助项目(编号:PT-KW08-C01)
