摘要
目的探讨Twist、Snail蛋白在喉鳞状细胞癌(喉鳞癌)组织中的表达及其临床意义。方法应用免疫组织化学法检测60例喉鳞癌组织、30例癌旁组织中Twist、Snail蛋白的表达情况。结果喉鳞癌组织中Twist的阳性表达为68.3%(41/60),Snail的阳性表达为71.7%(43/60),均显著高于癌旁组织中的表达率;在喉鳞癌组织中Twist、Snail蛋白的表达之间存在显著正相关,相关系数(r)为0.529(P<0.01)。结论喉鳞癌组织中存在Twist、Snail蛋白的高表达,两者的联合表达能增加肿瘤细胞侵袭力,促进喉鳞癌的浸润、转移。
Objective To study the expression and clinical significance of Twist and Snail in laryngeal squamous cell carcino- ma. Methods Expression of Twist and Snail was detected in 60 cases of laryngeal squamous cell carcinoma tissues and 30 cases of ad- jacent tissues by immunohistochemistry. Results The positive Twist expression was 68.3% in laryngeal squamous cell carcinoma,and the positive Snail was 71.7%, showing a significantly difference in the expression of Twist and Snail between carcinoma and adjacent tissues. There was a significant correlation between the expressions of Twist and Snail in laryngeal squamous cell carcinoma, r = 0. 529, P 〈 0.01. Conclusion The overexpression of Twist and Snail protein were found in laryngeal squamous cell carcinoma. Their co-ex- pression could contribute to the invasion and metastasis in laryngeal squamous cell carcinoma. They were valuable molecular markers to be used for monitoring the disease.
出处
《东南国防医药》
2013年第5期474-476,共3页
Military Medical Journal of Southeast China
关键词
喉鳞癌
TWIST蛋白
SNAIL蛋白
laryngeal squamous cell carcinoma
twist protein
snail protein
