摘要
背景:随访研究表明,肾移植对供肾者的安全影响较正常人群无统计学差异,甚至有更高的生活质量。目的:评价亲属活体肾移植对供者的安全性影响。方法:通过门诊定期随访、配合电话随访以及定期举办肾友会的方式对94例亲属活体肾移植后供者随访1-10年,比较肾移植供者供肾前后血清肌酐、血尿和尿蛋白以及血压和血脂的变化情况。结果与结论:供者供肾后出院时血清肌酐较供肾前明显升高(P<0.01),但仍在正常范围内,且保持在稳定水平,最近一次随访时血清肌酐与出院时差异无显著性意义(P>0.05)。供者供肾后镜下血尿3例(3.2%)、蛋白尿2例(2.1%),经休息后可好转;高血压6例(6.4%);高脂血症6例(6.4%);无一例供者死亡。说明对于健康供者而言,供肾是安全可行的,供肾前全面评估和供肾后长期随访对保障供者的安全有十分重要的意义。
BACKGROUND：Fol ow-up researches have shown that there is no statistical y difference in safety between kidney donor and healthy person after kidney transplantation, even the donors wil have better life quality. OBJECTIVE：To evaluate the safety of living-related kidney transplantation in living kidney donors. METHODS：Ninety-four cases of kidney donors received 1-10 years fol ow-up through regular clinical fol ow-up, telephone fol ow-up and regular renal patients self-help groups to compare the changes of serum creatinine, hematuria, proteinuria and blood pressure and lipid level in the donors before and after kidney transplantation. RESULTS AND CONCLUSION：The serum creatinine was significantly increased after nephrectomy （P〈0.01）, but al the donors had normal serum creatinine levels and remained stable. There was no significant difference in serum creatinine level between the latest fol ow-up and discharge （P〉0.05）. After nephrectomy, three cases （3.2%） suffered from hematuria, two cases （2.1%） had proteinuria, and improved after rest;six cases （6.4%） were subject to hypertension and six cases （6.4%） to hyperlipidemia. Al of the donors were alive. The living donor nephrectomy is feasible and safe. Preoperative assessment and long-term postoperative fol ow-up can guarantee the safety of the donors.
出处
《中国组织工程研究》
CAS
CSCD
2013年第44期7681-7686,共6页
Chinese Journal of Tissue Engineering Research
基金
上海市科委基础研究重点项目(11JC1416100)~~
