摘要
目的分析2006-2011年我院环丙沙星用药频度与常见革兰阴性杆菌耐药率,探讨两者之间的相关性。方法采用回顾性调查方法,对2006-2011年环丙沙星使用强度的年用量进行汇总,计算抗菌药物的年用药频度(DDDs),并对DDDs与常见5种革兰阴性菌耐药率进行相关性分析。结果 2006-2010年环丙沙星用药频度呈下降趋势,2011年略有提高。大肠埃希菌对环丙沙星耐药率较高,均超过60%,但未超过75%。肺炎克雷伯菌、铜绿假单胞菌对环丙沙星耐药率较低,约为30%,均未超过40%。阴沟肠杆菌对环丙沙星耐药率除2007年超过50%,其对环丙沙星耐药率亦较低,约为30%,均未超过40%。鲍曼不动杆菌对环丙沙星耐药率呈上升趋势,2008年耐药率最高,超过75%。耐药率与用药频度相关性分析显示,铜绿假单胞菌对环丙沙星的耐药率与用药频度存在负相关(r=-0.933,P<0.01)。肺炎克雷伯菌对环丙沙星无相关关系。结论铜绿假单胞菌对环丙沙星的耐药率与用药频度存在高度相关。
Objective To analyze the relationship of the ciprofloxacin consumption and the drug resistance rates of 5 kinds of Gram-negative bacteria in our hospital from 2006 to 2011. Methods The yearly consumption of ciprofloxacin prescribed in our hospital and the resistance rates of 5 kinds of gram-negative bacteria in the 6 years were analyzed retrospectively. DDDs were calculated. The relationship between the resistance and the quantity was analyzed. Results The DDDs of ciprofloxacin had downward trends from 2006 to 2010,but it had a small growth in 2011. Escerichia coli resistance was relatively high（ 60% -75 % ） ;Klebsiella pneumoniae and pseudomonas aeruginosa resistance were relatively low（30% -40% ）. Enterobacter cloacae resistance rate was 30% -40% , but the rate was more than 50% in 2007. Acinetobacter baumannii resistance had a growing trend,it was the highest in 2008 （ 〉 75% ）. A negative relationship between pseudomonas aeruginosa and DDDs of ciprofloxacin was found（ r = -0. 933, P 〈 0. 01 ）. No correlation between the resistance rate of Klebsiella pneumoniae and DDDs of ciprofloxacin was found. Conclusion There is a negative correlation between the resistance rate of pseudomonas aeruginosa and DDDs of ciprofloxacin.
出处
《实用药物与临床》
CAS
2013年第10期957-959,共3页
Practical Pharmacy and Clinical Remedies
