摘要
目的调查2008-2013年本院鲍曼不动杆菌的分布、耐药性及抗菌药物用药频度与耐药性的相关性。方法回顾性分析鲍曼不动杆菌的分布及药敏结果,计算用药频度(DDDs),分析抗菌药物的使用趋势,对耐药率与用药频度相关性进行分析。结果鲍曼不动杆菌对各种抗菌药物的耐药率不稳定,鲍曼不动杆菌的耐药率与哌拉西林/他唑巴坦用量呈负相关,至2013年常用抗菌药物对鲍曼不动杆菌的敏感率均不超过50%。结论鲍曼不动杆菌的耐药率高且呈多药耐药。
Objective To investigate the distribution and antimicrobial resistance of clinical isolates of Acinetobacter baumannii isolated from our hospitalized patients from 2008 to 2013,and analyze the correlation between the medication frequency and the drug resistance.Methods The distribution and the drug susceptibility testing for Acinetobacter baumannii isolated from clinical specimens were retrospectively analyzed.The using trend of antibiotics was analyzed by calculation the DDDs.The relationship between the drug resistance rate and defined daily dose（DDDs） was statistically analyzed.Results Acinetobacter baumannii varied in drug resistance,the drug resistance rates to penicillins,cephalosporins,quinolones,and carbapenems were high.In 2013,no antibacterial drugs is sensitive to Acinetobacter baumannii rate of more than 50%.The resistance rate of Acinetobacter baumannii was negatively correlated with the dosage of piperacillin / tazobactam.Conclusion The resistance rate of Acinetobacter baumannii is high.And the isolates are multidrug resistant.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第13期1312-1314,共3页
The Chinese Journal of Clinical Pharmacology
关键词
鲍曼不动杆菌
耐药性
抗菌药物
用药频度
相关性
Acinetobacter baumannii
drug resistance
antibiotics
defined daily dose
correlation
